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Research Article

Network-based Survival Analysis Reveals Subnetwork Signatures for Predicting Outcomes of Ovarian Cancer Treatment

  • Wei Zhang,

    Affiliation: Department of Computer Science and Engineering, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America

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  • Takayo Ota,

    Affiliation: Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

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  • Viji Shridhar,

    Affiliation: Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

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  • Jeremy Chien,

    Affiliation: Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

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  • Baolin Wu,

    Affiliation: Division of Biostatistics, School of Public Health, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America

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  • Rui Kuang mail

    kuang@cs.umn.edu

    Affiliation: Department of Computer Science and Engineering, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America

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  • Published: March 21, 2013
  • DOI: 10.1371/journal.pcbi.1002975

About the Authors

Wei Zhang, Rui Kuang
Department of Computer Science and Engineering, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America
Takayo Ota, Viji Shridhar, Jeremy Chien
Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
Baolin Wu
Division of Biostatistics, School of Public Health, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America

Corresponding Author

Email: kuang@cs.umn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WZ VS JC BW RK. Performed the experiments: WZ TO. Analyzed the data: WZ JC BW RK. Contributed reagents/materials/analysis tools: TO VS JC. Wrote the paper: WZ JC BW RK.