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Research Article

A Computational Model Predicting Disruption of Blood Vessel Development

  • Nicole Kleinstreuer,

    Affiliation: National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

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  • David Dix,

    Affiliation: National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

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  • Michael Rountree,

    Affiliation: National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

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  • Nancy Baker,

    Affiliation: Lockheed-Martin, Research Triangle Park, North Carolina, United States of America

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  • Nisha Sipes,

    Affiliation: National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

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  • David Reif,

    Affiliation: National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

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  • Richard Spencer,

    Affiliation: Lockheed-Martin, Research Triangle Park, North Carolina, United States of America

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  • Thomas Knudsen mail

    knudsen.thomas@epa.gov

    Affiliation: National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

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  • Published: April 04, 2013
  • DOI: 10.1371/journal.pcbi.1002996

About the Authors

Nicole Kleinstreuer, David Dix, Michael Rountree, Nisha Sipes, David Reif, Thomas Knudsen
National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America
Nancy Baker, Richard Spencer
Lockheed-Martin, Research Triangle Park, North Carolina, United States of America

Corresponding Author

Email: knudsen.thomas@epa.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NK DD TK. Performed the experiments: NK. Analyzed the data: NK. Contributed reagents/materials/analysis tools: NK MR NB NS DR RS. Wrote the paper: NK TK.