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Research Article

Connecting the Kinetics and Energy Landscape of tRNA Translocation on the Ribosome

  • Paul C. Whitford mail,

    p.whitford@neu.edu

    Affiliations: Department of Physics, Northeastern University, Boston, Massachusetts, United States of America, Center for Theoretical Biological Physics, Rice University, Houston, Texas, United States of America, Theoretical Biology and Biophysics, Theoretical Division, Los Alamos National Laboratory, MS K710, Los Alamos, New Mexico, United States of America

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  • Scott C. Blanchard,

    Affiliation: Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, New York, United States of America

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  • Jamie H. D. Cate,

    Affiliations: Departments of Molecular and Cell Biology and Chemistry, University of California at Berkeley, Berkeley, California, United States of America, Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

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  • Karissa Y. Sanbonmatsu

    Affiliation: Theoretical Biology and Biophysics, Theoretical Division, Los Alamos National Laboratory, MS K710, Los Alamos, New Mexico, United States of America

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  • Published: March 21, 2013
  • DOI: 10.1371/journal.pcbi.1003003

About the Authors

Paul C. Whitford
Department of Physics, Northeastern University, Boston, Massachusetts, United States of America
Paul C. Whitford
Center for Theoretical Biological Physics, Rice University, Houston, Texas, United States of America
Paul C. Whitford, Karissa Y. Sanbonmatsu
Theoretical Biology and Biophysics, Theoretical Division, Los Alamos National Laboratory, MS K710, Los Alamos, New Mexico, United States of America
Scott C. Blanchard
Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, New York, United States of America
Jamie H. D. Cate
Departments of Molecular and Cell Biology and Chemistry, University of California at Berkeley, Berkeley, California, United States of America
Jamie H. D. Cate
Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Corresponding Author

Email: p.whitford@neu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PCW KYS. Performed the experiments: PCW KYS. Analyzed the data: PCW SCB JHDC KYS. Contributed reagents/materials/analysis tools: PCW. Wrote the paper: PCW SCB JHDC KYS.