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Research Article

Cleavage Entropy as Quantitative Measure of Protease Specificity

  • Julian E. Fuchs,

    Affiliation: Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria

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  • Susanne von Grafenstein,

    Affiliation: Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria

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  • Roland G. Huber,

    Affiliation: Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria

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  • Michael A. Margreiter,

    Affiliation: Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria

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  • Gudrun M. Spitzer,

    Affiliation: Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria

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  • Hannes G. Wallnoefer,

    Affiliation: Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria

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  • Klaus R. Liedl mail

    klaus.liedl@uibk.ac.at

    Affiliation: Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria

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  • Published: April 18, 2013
  • DOI: 10.1371/journal.pcbi.1003007

About the Authors

Julian E. Fuchs, Susanne von Grafenstein, Roland G. Huber, Michael A. Margreiter, Gudrun M. Spitzer, Hannes G. Wallnoefer, Klaus R. Liedl
Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria

Corresponding Author

Email: klaus.liedl@uibk.ac.at

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JEF SvG RGH MAM HGW KRL. Performed the experiments: JEF. Analyzed the data: JEF SvG RGH MAM GMS HGW KRL. Contributed reagents/materials/analysis tools: JEF SvG HGW KRL. Wrote the paper: JEF SvG RGH MAM GMS HGW KRL.