Advertisement
Research Article

Data-Driven Modeling of Src Control on the Mitochondrial Pathway of Apoptosis: Implication for Anticancer Therapy Optimization

  • Annabelle Ballesta mail,

    annabelle.ballesta@inria.fr

    Affiliation: BANG project team, INRIA Rocquencourt, Le Chesnay, Yvelines, France

    X
  • Jonathan Lopez,

    Affiliations: Centre de Recherche en Cancérologie de Lyon, INSERM U1052/CNRS UMR5286, Lyon, Rhône, France, Université de Lyon - Université Claude Bernard Lyon 1, Lyon, Rhône, France, Hospices Civils de Lyon - Fédération de Biochimie Nord - Hôpital de la Croix Rousse, Lyon, Rhône, France

    X
  • Nikolay Popgeorgiev,

    Affiliations: Centre de Recherche en Cancérologie de Lyon, INSERM U1052/CNRS UMR5286, Lyon, Rhône, France, Université de Lyon - Université Claude Bernard Lyon 1, Lyon, Rhône, France

    X
  • Philippe Gonzalo,

    Affiliations: Centre de Recherche en Cancérologie de Lyon, INSERM U1052/CNRS UMR5286, Lyon, Rhône, France, Université de Lyon - Université Claude Bernard Lyon 1, Lyon, Rhône, France, Hospices Civils de Lyon - Fédération de Biochimie Nord - Hôpital de la Croix Rousse, Lyon, Rhône, France

    X
  • Marie Doumic ,

    Affiliation: BANG project team, INRIA Rocquencourt, Le Chesnay, Yvelines, France

    These authors equally supervised this work.

    X
  • Germain Gillet

    Affiliations: Centre de Recherche en Cancérologie de Lyon, INSERM U1052/CNRS UMR5286, Lyon, Rhône, France, Université de Lyon - Université Claude Bernard Lyon 1, Lyon, Rhône, France

    These authors equally supervised this work.

    X
  • Published: April 04, 2013
  • DOI: 10.1371/journal.pcbi.1003011

About the Authors

Annabelle Ballesta, Marie Doumic
BANG project team, INRIA Rocquencourt, Le Chesnay, Yvelines, France
Jonathan Lopez, Nikolay Popgeorgiev, Philippe Gonzalo, Germain Gillet
Centre de Recherche en Cancérologie de Lyon, INSERM U1052/CNRS UMR5286, Lyon, Rhône, France
Jonathan Lopez, Nikolay Popgeorgiev, Philippe Gonzalo, Germain Gillet
Université de Lyon - Université Claude Bernard Lyon 1, Lyon, Rhône, France
Jonathan Lopez, Philippe Gonzalo
Hospices Civils de Lyon - Fédération de Biochimie Nord - Hôpital de la Croix Rousse, Lyon, Rhône, France

Corresponding Author

Email: annabelle.ballesta@inria.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Mathematical modeling, parameter estimation and computational procedure for optimization: AB MD. Conceived and designed the experiments: AB JL PG MD GG. Performed the experiments: JL NP PG. Analyzed the data: AB JL PG MD GG. Contributed reagents/materials/analysis tools: AB JL PG MD GG. Wrote the paper: AB JL PG MD GG.