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Research Article

Phosphorylation of the Retinoic Acid Receptor Alpha Induces a Mechanical Allosteric Regulation and Changes in Internal Dynamics

  • Yassmine Chebaro,

    Affiliation: Institute of Genetics and Molecular and Cellular Biology, Integrated Structural Biology Department, Illkirch, France

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  • Ismail Amal,

    Affiliation: Institute of Genetics and Molecular and Cellular Biology, Integrated Structural Biology Department, Illkirch, France

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  • Natacha Rochel,

    Affiliation: Institute of Genetics and Molecular and Cellular Biology, Integrated Structural Biology Department, Illkirch, France

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  • Cécile Rochette-Egly,

    Affiliation: Institute of Genetics and Molecular and Cellular Biology, Functional Genomics and Cancer Department, Illkirch, France

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  • Roland H. Stote mail,

    rstote@igbmc.fr (RHS); annick@igbmc.fr (AD)

    Affiliation: Institute of Genetics and Molecular and Cellular Biology, Integrated Structural Biology Department, Illkirch, France

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  • Annick Dejaegere mail

    rstote@igbmc.fr (RHS); annick@igbmc.fr (AD)

    Affiliation: Institute of Genetics and Molecular and Cellular Biology, Integrated Structural Biology Department, Illkirch, France

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  • Published: April 18, 2013
  • DOI: 10.1371/journal.pcbi.1003012

About the Authors

Yassmine Chebaro, Ismail Amal, Natacha Rochel, Roland H. Stote, Annick Dejaegere
Institute of Genetics and Molecular and Cellular Biology, Integrated Structural Biology Department, Illkirch, France
Cécile Rochette-Egly
Institute of Genetics and Molecular and Cellular Biology, Functional Genomics and Cancer Department, Illkirch, France

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YC RHS AD. Performed the experiments: YC IA. Analyzed the data: YC RHS AD. Wrote the paper: YC NR CRE RHS AD.