Advertisement
Research Article

Synthetic Lethality between Gene Defects Affecting a Single Non-essential Molecular Pathway with Reversible Steps

  • Andrei Zinovyev equal contributor mail,

    equal contributor Contributed equally to this work with: Andrei Zinovyev, Inna Kuperstein

    Andrei.Zinovyev@curie.fr (AZ); wdheyer@ucdavis.edu (WDH)

    Affiliations: Institut Curie, Paris, France, INSERM, U900, Paris, France, Mines ParisTech, Fontainebleau, France

    X
  • Inna Kuperstein equal contributor,

    equal contributor Contributed equally to this work with: Andrei Zinovyev, Inna Kuperstein

    Affiliations: Institut Curie, Paris, France, INSERM, U900, Paris, France, Mines ParisTech, Fontainebleau, France

    X
  • Emmanuel Barillot,

    Affiliations: Institut Curie, Paris, France, INSERM, U900, Paris, France, Mines ParisTech, Fontainebleau, France

    X
  • Wolf-Dietrich Heyer mail

    Andrei.Zinovyev@curie.fr (AZ); wdheyer@ucdavis.edu (WDH)

    Affiliation: Departments of Microbiology & Molecular Genetics and of Molecular & Cellular Biology, University of California, Davis, Davis, California, United States of America

    X
  • Published: April 04, 2013
  • DOI: 10.1371/journal.pcbi.1003016

About the Authors

Andrei Zinovyev, Inna Kuperstein, Emmanuel Barillot
Institut Curie, Paris, France
Andrei Zinovyev, Inna Kuperstein, Emmanuel Barillot
INSERM, U900, Paris, France
Andrei Zinovyev, Inna Kuperstein, Emmanuel Barillot
Mines ParisTech, Fontainebleau, France
Wolf-Dietrich Heyer
Departments of Microbiology & Molecular Genetics and of Molecular & Cellular Biology, University of California, Davis, Davis, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AZ IK WDH. Performed the experiments: AZ. Analyzed the data: AZ IK EB WDH. Wrote the paper: AZ IK EB WDH.