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Research Article

Biomarker Discovery by Sparse Canonical Correlation Analysis of Complex Clinical Phenotypes of Tuberculosis and Malaria

  • Juho Rousu,

    Affiliations: Helsinki Institute for Information Technology, Department of Information and Computer Science, Aalto University, Espoo, Finland, Childhood Malaria Research Group, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria

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  • Daniel D. Agranoff,

    Affiliation: Department of Infectious Diseases and Immunity and Wellcome Trust Centre for Clinical Tropical Medicine, Imperial College London, London, United Kingdom

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  • Olugbemiro Sodeinde,

    Affiliations: Childhood Malaria Research Group, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria, Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, London, United Kingdom

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  • John Shawe-Taylor,

    Affiliation: Department of Computer Science, University College London, London, United Kingdom

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  • Delmiro Fernandez-Reyes mail

    dfernan@nimr.mrc.ac.uk

    Affiliations: Childhood Malaria Research Group, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria, Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, London, United Kingdom, Department of Computer Science, University College London, London, United Kingdom

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  • Published: April 18, 2013
  • DOI: 10.1371/journal.pcbi.1003018

About the Authors

Juho Rousu
Helsinki Institute for Information Technology, Department of Information and Computer Science, Aalto University, Espoo, Finland
Juho Rousu, Olugbemiro Sodeinde, Delmiro Fernandez-Reyes
Childhood Malaria Research Group, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria
Daniel D. Agranoff
Department of Infectious Diseases and Immunity and Wellcome Trust Centre for Clinical Tropical Medicine, Imperial College London, London, United Kingdom
Olugbemiro Sodeinde, Delmiro Fernandez-Reyes
Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, London, United Kingdom
John Shawe-Taylor, Delmiro Fernandez-Reyes
Department of Computer Science, University College London, London, United Kingdom

Corresponding Author

Email: dfernan@nimr.mrc.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JR JST DFR. Performed the experiments: JR DFR. Analyzed the data: JR DDA OS JST DFR. Contributed reagents/materials/analysis tools: DDA OS DFR. Wrote the paper: JR JST DFR.