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Research Article

Ab Initio Modeling and Experimental Assessment of Janus Kinase 2 (JAK2) Kinase-Pseudokinase Complex Structure

  • Xiaobo Wan equal contributor,

    equal contributor Contributed equally to this work with: Xiaobo Wan, Yue Ma

    Affiliations: Graduate School in Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, National Institute of Biological Sciences, Beijing, Zhongguancun Life Science Park, Changping District, Beijing, China

    X
  • Yue Ma equal contributor,

    equal contributor Contributed equally to this work with: Xiaobo Wan, Yue Ma

    Affiliation: Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

    X
  • Christopher L. McClendon,

    Affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, California, United States of America

    X
  • Lily Jun-shen Huang mail,

    Lily.Huang@UTSouthwestern.edu (LJH); huangniu@nibs.ac.cn (NH)

    Affiliation: Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

    X
  • Niu Huang mail

    Lily.Huang@UTSouthwestern.edu (LJH); huangniu@nibs.ac.cn (NH)

    Affiliations: Graduate School in Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, National Institute of Biological Sciences, Beijing, Zhongguancun Life Science Park, Changping District, Beijing, China

    X
  • Published: April 04, 2013
  • DOI: 10.1371/journal.pcbi.1003022

About the Authors

Xiaobo Wan, Niu Huang
Graduate School in Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Xiaobo Wan, Niu Huang
National Institute of Biological Sciences, Beijing, Zhongguancun Life Science Park, Changping District, Beijing, China
Yue Ma, Lily Jun-shen Huang
Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
Christopher L. McClendon
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XW LJH NH. Performed the experiments: XW YM. Analyzed the data: XW NH. Contributed reagents/materials/analysis tools: CLM. Wrote the paper: XW LJH NH.