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Research Article

Malaria's Missing Number: Calculating the Human Component of R0 by a Within-Host Mechanistic Model of Plasmodium falciparum Infection and Transmission

  • Geoffrey L. Johnston,

    Affiliations: Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York, United States of America, School of International and Public Affairs, Columbia University, New York, New York, United States of America, Bloomberg School of Public Health, John Hopkins University, Baltimore, Maryland, United States of America

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  • David L. Smith mail,

    dlsmith@jhsph.edu (DLS); df2260@columbia.edu (DAF)

    Affiliation: Bloomberg School of Public Health, John Hopkins University, Baltimore, Maryland, United States of America

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  • David A. Fidock mail

    dlsmith@jhsph.edu (DLS); df2260@columbia.edu (DAF)

    Affiliations: Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York, United States of America, Division of Infectious Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, United States of America

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  • Published: April 18, 2013
  • DOI: 10.1371/journal.pcbi.1003025

About the Authors

Geoffrey L. Johnston, David A. Fidock
Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York, United States of America
Geoffrey L. Johnston
School of International and Public Affairs, Columbia University, New York, New York, United States of America
Geoffrey L. Johnston, David L. Smith
Bloomberg School of Public Health, John Hopkins University, Baltimore, Maryland, United States of America
David A. Fidock
Division of Infectious Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GLJ DLS DAF. Performed the experiments: GLJ. Analyzed the data: GLJ DLS DAF. Wrote the paper: GLJ DLS DAF.