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Research Article

Distinct Types of Disorder in the Human Proteome: Functional Implications for Alternative Splicing

  • Recep Colak equal contributor,

    equal contributor Contributed equally to this work with: Recep Colak, TaeHyung Kim

    Affiliations: The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada, Department of Computer Science, University of Toronto, Toronto, Ontario, Canada

    X
  • TaeHyung Kim equal contributor,

    equal contributor Contributed equally to this work with: Recep Colak, TaeHyung Kim

    Affiliations: The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada, Department of Computer Science, University of Toronto, Toronto, Ontario, Canada

    X
  • Magali Michaut,

    Affiliations: The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada

    X
  • Mark Sun,

    Affiliations: The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada, Department of Computer Science, University of Toronto, Toronto, Ontario, Canada

    X
  • Manuel Irimia,

    Affiliations: The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada

    X
  • Jeremy Bellay,

    Affiliation: Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America

    X
  • Chad L. Myers,

    Affiliation: Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America

    X
  • Benjamin J. Blencowe mail,

    b.blencowe@utoronto.ca (BJB); pi@kimlab.org (PMK)

    Affiliations: The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada

    X
  • Philip M. Kim mail

    b.blencowe@utoronto.ca (BJB); pi@kimlab.org (PMK)

    Affiliations: The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada, Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

    X
  • Published: April 25, 2013
  • DOI: 10.1371/journal.pcbi.1003030

About the Authors

Recep Colak, TaeHyung Kim, Magali Michaut, Mark Sun, Manuel Irimia, Benjamin J. Blencowe, Philip M. Kim
The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada
Recep Colak, TaeHyung Kim, Magali Michaut, Mark Sun, Manuel Irimia, Benjamin J. Blencowe, Philip M. Kim
Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada
Recep Colak, TaeHyung Kim, Mark Sun
Department of Computer Science, University of Toronto, Toronto, Ontario, Canada
Jeremy Bellay, Chad L. Myers, Philip M. Kim
Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America
Philip M. Kim
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RC BJB PMK. Performed the experiments: RC TK MS MI. Analyzed the data: RC TK MS PMK. Contributed reagents/materials/analysis tools: MM MS JB CLM. Wrote the paper: RC BJB PMK.