About the Authors

Christian A. Tiemann

c.a.tiemann@tue.nl

Affiliations Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands, Netherlands Consortium for Systems Biology, University of Amsterdam, Amsterdam, The Netherlands

Joep Vanlier

Affiliations Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands, Netherlands Consortium for Systems Biology, University of Amsterdam, Amsterdam, The Netherlands

Maaike H. Oosterveer

Affiliation Department of Pediatrics, University Groningen, University Medical Center Groningen, Groningen, The Netherlands

Albert K. Groen

Affiliations Netherlands Consortium for Systems Biology, University of Amsterdam, Amsterdam, The Netherlands, Department of Pediatrics, University Groningen, University Medical Center Groningen, Groningen, The Netherlands, Department of Laboratory Medicine, University Groningen, University Medical Center Groningen, Groningen, The Netherlands

Peter A. J. Hilbers

Affiliations Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands, Netherlands Consortium for Systems Biology, University of Amsterdam, Amsterdam, The Netherlands

Natal A. W. van Riel

Affiliations Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands, Netherlands Consortium for Systems Biology, University of Amsterdam, Amsterdam, The Netherlands

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MHO AKG. Performed the experiments: MHO. Wrote the paper: CAT. Developed the mathematical model: CAT. Developed the computational approach: CAT. Developed software to simulate compiled ODE. models in Matlab: JV. Analysed the computational results: CAT JV MHO AKG PAJH NAWvR. Revised the paper: JV MHO AKG PAJH NAWvR. Supervised the study: AKG PAJH NAWvR.