About the Authors

Karen van Eunen

Affiliations Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Netherlands Consortium for Systems Biology, Amsterdam, The Netherlands

Sereh M. J. Simons

Affiliation Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Albert Gerding

Affiliations Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Department of Laboratory Medicine, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Aycha Bleeker

Affiliation Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Gijs den Besten

Affiliations Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Netherlands Consortium for Systems Biology, Amsterdam, The Netherlands

Catharina M. L. Touw

Affiliation Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Sander M. Houten

Affiliation Laboratory Genetic Metabolic Diseases, Departments of Clinical Chemistry and Pediatrics, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Bert K. Groen

Affiliations Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Netherlands Consortium for Systems Biology, Amsterdam, The Netherlands

Klaas Krab

Affiliation Department of Molecular Cell Physiology, Netherlands Institute for Systems Biology, VU University Amsterdam, Amsterdam, The Netherlands

Dirk-Jan Reijngoud

Affiliations Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Netherlands Consortium for Systems Biology, Amsterdam, The Netherlands, Department of Laboratory Medicine, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Barbara M. Bakker

b.m.bakker01@umcg.nl

Affiliations Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Netherlands Consortium for Systems Biology, Amsterdam, The Netherlands

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KvE SMH BKG KK DJR BMB. Performed the experiments: KvE SMJS AG AB GdB. Analyzed the data: KvE SMJS AG. Wrote the paper: KvE BMB. Interpretation of the results: KvE SMJS AG AB GdB CMLT SMH BKG KK DJR BMB.