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Research Article

Flux Imbalance Analysis and the Sensitivity of Cellular Growth to Changes in Metabolite Pools

  • Ed Reznik,

    Affiliation: Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

    Current address: Computational Biology Center, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.

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  • Pankaj Mehta,

    Affiliations: Department of Physics, Boston University, Boston, Massachusetts, United States of America, Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America

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  • Daniel Segrè mail

    dsegre@bu.edu

    Affiliations: Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America, Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America, Department of Biology, Boston University, Boston, Massachusetts, United States of America

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  • Published: August 29, 2013
  • DOI: 10.1371/journal.pcbi.1003195

About the Authors

Ed Reznik, Daniel Segrè
Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America
Pankaj Mehta
Department of Physics, Boston University, Boston, Massachusetts, United States of America
Pankaj Mehta, Daniel Segrè
Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America
Daniel Segrè
Department of Biology, Boston University, Boston, Massachusetts, United States of America

Corresponding Author

Email: dsegre@bu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ER PM DS. Performed the experiments: ER. Analyzed the data: ER PM DS. Wrote the paper: ER PM DS.