About the Authors

Francisco Martínez-Jiménez

Affiliations Genome Biology Group, Centre Nacional d'Anàlisi Genòmica (CNAG), Barcelona, Spain, Gene Regulation Stem Cells and Cancer Program, Centre for Genomic Regulation (CRG), Barcelona, Spain

George Papadatos

Affiliation European Molecular Biology Laboratory – European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

Lun Yang

Affiliation Computational Biology, Quantitative Sciences, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Iain M. Wallace

Affiliation European Molecular Biology Laboratory – European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

Vinod Kumar

Affiliation Computational Biology, Quantitative Sciences, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Ursula Pieper

Affiliation Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, United States of America

Andrej Sali

Affiliation Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, United States of America

James R. Brown

James.R.Brown@gsk.com (JRB); jpo@ebi.ac.uk (JPO); mmarti@pcb.ub.cat (MAMR)

Affiliation Computational Biology, Quantitative Sciences, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

John P. Overington

James.R.Brown@gsk.com (JRB); jpo@ebi.ac.uk (JPO); mmarti@pcb.ub.cat (MAMR)

Affiliation European Molecular Biology Laboratory – European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

Marc A. Marti-Renom

James.R.Brown@gsk.com (JRB); jpo@ebi.ac.uk (JPO); mmarti@pcb.ub.cat (MAMR)

Affiliations Genome Biology Group, Centre Nacional d'Anàlisi Genòmica (CNAG), Barcelona, Spain, Gene Regulation Stem Cells and Cancer Program, Centre for Genomic Regulation (CRG), Barcelona, Spain

Competing Interests

VK, LY, and JRB are paid employees of GlaxoSmithKline (GSK). This does not alter our adherence to the PLOS policies on sharing data and materials. All other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JRB JPO MAMR. Performed the experiments: FMJ GP LY IMW VK UP. Analyzed the data: FMJ GP LY MAMR. Contributed reagents/materials/analysis tools: IMW VK UP. Wrote the paper: FMJ GP AS JRB JPO MAMR.