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Research Article

A Virtual Infection Model Quantifies Innate Effector Mechanisms and Candida albicans Immune Escape in Human Blood

  • Kerstin Hünniger equal contributor,

    equal contributor Contributed equally to this work with: Kerstin Hünniger, Teresa Lehnert

    Affiliation: Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute (HKI), Jena, Germany

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  • Teresa Lehnert equal contributor,

    equal contributor Contributed equally to this work with: Kerstin Hünniger, Teresa Lehnert

    Affiliations: Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute (HKI), Jena, Germany, Friedrich Schiller University Jena, Jena, Germany

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  • Kristin Bieber,

    Affiliation: Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute (HKI), Jena, Germany

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  • Ronny Martin,

    Affiliation: Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute (HKI), Jena, Germany

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  • Marc Thilo Figge mail,

    thilo.figge@hki-jena.de (MTF); oliver.kurzai@hki-jena.de (OK)

    Affiliations: Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute (HKI), Jena, Germany, Friedrich Schiller University Jena, Jena, Germany

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  • Oliver Kurzai mail

    thilo.figge@hki-jena.de (MTF); oliver.kurzai@hki-jena.de (OK)

    Affiliation: Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute (HKI), Jena, Germany

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  • Published: February 20, 2014
  • DOI: 10.1371/journal.pcbi.1003479

About the Authors

Kerstin Hünniger, Kristin Bieber, Ronny Martin, Oliver Kurzai
Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute (HKI), Jena, Germany
Teresa Lehnert, Marc Thilo Figge
Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute (HKI), Jena, Germany
Teresa Lehnert, Marc Thilo Figge
Friedrich Schiller University Jena, Jena, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KH TL MTF OK. Performed the experiments: KH TL KB RM. Analyzed the data: KH TL MTF OK. Contributed reagents/materials/analysis tools: RM. Wrote the paper: KH TL MTF OK.