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Research Article

GAGA: A New Algorithm for Genomic Inference of Geographic Ancestry Reveals Fine Level Population Substructure in Europeans

  • Oscar Lao mail,

    o.laogrueso@erasmusmc.nl

    Affiliation: Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands

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  • Fan Liu,

    Affiliation: Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands

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  • Andreas Wollstein,

    Affiliations: Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands

    Current address: Section of Evolutionary Biology, Department of Biology II, University of Munich LMU, Planegg-Martinsried, Germany.

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  • Manfred Kayser

    Affiliation: Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands

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  • Published: February 20, 2014
  • DOI: 10.1371/journal.pcbi.1003480

About the Authors

Oscar Lao, Fan Liu, Andreas Wollstein, Manfred Kayser
Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
Andreas Wollstein
Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands

Corresponding Author

Email: o.laogrueso@erasmusmc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: OL FL. Performed the experiments: OL FL AW. Analyzed the data: OL FL AW. Contributed reagents/materials/analysis tools: MK. Wrote the paper: OL FL MK.