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Research Article

ODE Constrained Mixture Modelling: A Method for Unraveling Subpopulation Structures and Dynamics

  • Jan Hasenauer mail,

    jan.hasenauer@helmholtz-muenchen.de

    Affiliations: Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany, Division of Mathematical Modeling of Biological Systems, Department of Mathematics, University of Technology Munich, Munich, Germany

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  • Christine Hasenauer,

    Affiliation: Max Planck Institute for Molecular Genetics, Berlin, Germany

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  • Tim Hucho,

    Affiliations: Max Planck Institute for Molecular Genetics, Berlin, Germany, Division of Experimental Anesthesiology and Pain Research, Department of Anesthesiology and Intensive Care Medicine, University Hospital Cologne, Cologne, Germany

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  • Fabian J. Theis

    Affiliations: Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany, Division of Mathematical Modeling of Biological Systems, Department of Mathematics, University of Technology Munich, Munich, Germany

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  • Published: July 03, 2014
  • DOI: 10.1371/journal.pcbi.1003686

About the Authors

Jan Hasenauer, Fabian J. Theis
Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany
Jan Hasenauer, Fabian J. Theis
Division of Mathematical Modeling of Biological Systems, Department of Mathematics, University of Technology Munich, Munich, Germany
Christine Hasenauer, Tim Hucho
Max Planck Institute for Molecular Genetics, Berlin, Germany
Tim Hucho
Division of Experimental Anesthesiology and Pain Research, Department of Anesthesiology and Intensive Care Medicine, University Hospital Cologne, Cologne, Germany

Corresponding Author

Email: jan.hasenauer@helmholtz-muenchen.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JH CH TH. Performed the experiments: CH. Analyzed the data: JH CH. Contributed reagents/materials/analysis tools: TH. Wrote the paper: JH CH. Developed and implemented the analysis tools: JH CH FJT.