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Research Article

Signaling Domain of Sonic Hedgehog as Cannibalistic Calcium-Regulated Zinc-Peptidase

  • Rocio Rebollido-Rios,

    Affiliation: Research Group Bioinformatics, Faculty of Biology, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany

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  • Shyam Bandari,

    Affiliation: Institute of Physiological Chemistry and Pathobiochemistry, Faculty of Medicine, University of Münster, Münster, Germany

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  • Christoph Wilms,

    Affiliation: Research Group Bioinformatics, Faculty of Biology, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany

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  • Stanislav Jakuschev,

    Affiliation: Research Group Bioinformatics, Faculty of Biology, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany

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  • Andrea Vortkamp,

    Affiliation: Department of Developmental Biology, Faculty of Biology, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany

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  • Kay Grobe mail,

    kgrobe@uni-muenster.de (KG); daniel.hoffmann@uni-due.de (DH)

    Affiliation: Institute of Physiological Chemistry and Pathobiochemistry, Faculty of Medicine, University of Münster, Münster, Germany

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  • Daniel Hoffmann mail

    kgrobe@uni-muenster.de (KG); daniel.hoffmann@uni-due.de (DH)

    Affiliation: Research Group Bioinformatics, Faculty of Biology, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany

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  • Published: July 17, 2014
  • DOI: 10.1371/journal.pcbi.1003707

About the Authors

Rocio Rebollido-Rios, Christoph Wilms, Stanislav Jakuschev, Daniel Hoffmann
Research Group Bioinformatics, Faculty of Biology, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany
Shyam Bandari, Kay Grobe
Institute of Physiological Chemistry and Pathobiochemistry, Faculty of Medicine, University of Münster, Münster, Germany
Andrea Vortkamp
Department of Developmental Biology, Faculty of Biology, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RRR SB KG DH. Performed the experiments: RRR SB CW KG DH. Analyzed the data: RRR SB CW AV KG DH. Contributed reagents/materials/analysis tools: SJ. Wrote the paper: RRR CW AV KG DH.