About the Authors

Kathryn A. Loving

kathryn_armstrong@alum.mit.edu (KAL); alan.cheng@amgen.com (ACC)

Affiliation Schrödinger LLC, New York, New York, United States of America

Andy Lin

Affiliation Amgen Inc., South San Francisco, California, United States of America

Alan C. Cheng

kathryn_armstrong@alum.mit.edu (KAL); alan.cheng@amgen.com (ACC)

Affiliation Amgen Inc., South San Francisco, California, United States of America

Competing Interests

ACC and AL were paid employees of Amgen, Inc., and KAL was a paid employee of Schrodinger, LLC. This does not alter our adherence to the PLOS policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ACC KAL. Performed the experiments: ACC KAL AL. Analyzed the data: ACC KAL AL. Contributed reagents/materials/analysis tools: ACC KAL AL. Wrote the paper: ACC KAL. Reviewed the manuscript: ACC KAL AL.