About the Authors

Eric L. Haseltine

Affiliation Vertex Pharmaceuticals Incorporated, Boston, Massachussets, United States of America

Sandra De Meyer

Affiliation Janssen Infectious Diseases BVBA, Beerse, Belgium

Inge Dierynck

Affiliation Janssen Infectious Diseases BVBA, Beerse, Belgium

Doug J. Bartels

Affiliation Vertex Pharmaceuticals Incorporated, Boston, Massachussets, United States of America

Anne Ghys

Affiliation Janssen Infectious Diseases BVBA, Beerse, Belgium

Andrew Davis

Affiliation Vertex Pharmaceuticals Incorporated, Boston, Massachussets, United States of America

Eileen Z. Zhang

Affiliation Vertex Pharmaceuticals Incorporated, Boston, Massachussets, United States of America

Ann M. Tigges

Affiliation Vertex Pharmaceuticals Incorporated, Boston, Massachussets, United States of America

Joan Spanks

Affiliation Vertex Pharmaceuticals Incorporated, Boston, Massachussets, United States of America

Gaston Picchio

Affiliation Janssen Research & Development, Titusville, New Jersey, United States of America

Tara L. Kieffer

Affiliation Vertex Pharmaceuticals Incorporated, Boston, Massachussets, United States of America

James C. Sullivan

James_Sullivan@vrtx.com

Affiliation Vertex Pharmaceuticals Incorporated, Boston, Massachussets, United States of America

Competing Interests

ELH, DJB, EZZ, TLK, and JCS are employees of Vertex Pharmaceuticals Incorporated and may own stock or stock options in that company. AD, AMT, JS, and ECM are former employees of Vertex Pharmaceuticals Incorporated and may own or may have owned stock or options in that company. SDM, ID, AG, and GP are employees of Janssen Pharmaceuticals, Inc. (a subsidiary of Johnson & Johnson) and may own stock or stock options in that company.

Author Contributions

Conceived and designed the experiments: SDM ID DJB AG AD EZZ AMT JS GP TLK JCS. Performed the experiments: ELH DJB AD EZZ AMT JS. Analyzed the data: ELH JCS SDM ID DJB AG AD EZZ AMT JS GP TLK. Contributed reagents/materials/analysis tools: ELH AD JCS AMT. Wrote the paper: ELH JCS TLK DJB.