August 2005

The cover image depicts a rendering of a Beta-helix structure formed by a polyglutamine peptide, putatively implicated in numerous protein-aggregation diseases. The merged image of the eye, the polyglutamine structure, and the simulation program code represents the ability to capture aggregation-prone protein conformations using computer simulations. (see Khare et al)

Image Credit: Image by Nikolay V. Dokholyan; polyglutamine structure visualized with PyMOL software.

Message from ISCB

ISMB 2005 Conference Report

B. J Morrison McKay

PLOS Computational Biology: published August 26, 2005 | https://doi.org/10.1371/journal.pcbi.0010033

Perspective

Will a Biological Database Be Different from a Biological Journal?

Philip Bourne

PLOS Computational Biology: published August 26, 2005 | https://doi.org/10.1371/journal.pcbi.0010034

Research Articles

Prediction of Transcriptional Terminators in Bacillus subtilis and Related Species

Michiel J. L. de Hoon, Yuko Makita, Kenta Nakai, Satoru Miyano

PLOS Computational Biology: published August 12, 2005 | https://doi.org/10.1371/journal.pcbi.0010025

Comparative Genomics and Disorder Prediction Identify Biologically Relevant SH3 Protein Interactions

Pedro Beltrao, Luis Serrano

PLOS Computational Biology: published August 12, 2005 | https://doi.org/10.1371/journal.pcbi.0010026

Comparative Analyses of Fundamental Differences in Membrane Transport Capabilities in Prokaryotes and Eukaryotes

Qinghu Ren, Ian T Paulsen

PLOS Computational Biology: published August 19, 2005 | https://doi.org/10.1371/journal.pcbi.0010027

Evidence of a Double-Lid Movement in Pseudomonas aeruginosa Lipase: Insights from Molecular Dynamics Simulations

Subbulakshmi Latha Cherukuvada, Aswin Sai Narain Seshasayee, Krishnan Raghunathan, Sharmila Anishetty, Gautam Pennathur

PLOS Computational Biology: published August 12, 2005 | https://doi.org/10.1371/journal.pcbi.0010028

Molecular Origin of Polyglutamine Aggregation in Neurodegenerative Diseases

Sagar D Khare, Feng Ding, Kenneth N Gwanmesia, Nikolay V Dokholyan

PLOS Computational Biology: published August 26, 2005 | https://doi.org/10.1371/journal.pcbi.0010030

Functional Coverage of the Human Genome by Existing Structures, Structural Genomics Targets, and Homology Models

Lei Xie, Philip E Bourne

PLOS Computational Biology: published August 19, 2005 | https://doi.org/10.1371/journal.pcbi.0010031

Evolution of Genetic Potential

Lauren Ancel Meyers, Fredric D Ancel, Michael Lachmann

PLOS Computational Biology: published August 26, 2005 | https://doi.org/10.1371/journal.pcbi.0010032

Correction

Correction: Improving the Precision of the Structure–Function Relationship by Considering Phylogenetic Context

Boris E Shakhnovich

PLOS Computational Biology: published August 26, 2005 | https://doi.org/10.1371/journal.pcbi.0010038

Cover

Representation of capturing aggregation-prone protein conformations using computer simulations