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Table of Contents: August 2005

Issue Image

The cover image depicts a rendering of a Beta-helix structure formed by a polyglutamine peptide, putatively implicated in numerous protein-aggregation diseases. The merged image of the eye, the polyglutamine structure, and the simulation program code represents the ability to capture aggregation-prone protein conformations using computer simulations. (see Khare et al)

Message from ISCB

ISMB 2005 Conference Report

B. J Morrison McKay

Perspective

Research Articles

Molecular Origin of Polyglutamine Aggregation in Neurodegenerative Diseases

Sagar D Khare, Feng Ding, Kenneth N Gwanmesia, Nikolay V Dokholyan

Evolution of Genetic Potential

Lauren Ancel Meyers, Fredric D Ancel, Michael Lachmann

Prediction of Transcriptional Terminators in Bacillus subtilis and Related Species

Michiel J. L. de Hoon, Yuko Makita, Kenta Nakai, Satoru Miyano

Evidence of a Double-Lid Movement in Pseudomonas aeruginosa Lipase: Insights from Molecular Dynamics Simulations

Subbulakshmi Latha Cherukuvada, Aswin Sai Narain Seshasayee, Krishnan Raghunathan, Sharmila Anishetty, Gautam Pennathur