November 2005

Shown here is a symmetric model of tetrameric acetylcholinesterase assembled with collagen Q tail (yellow in the middle). The peripheral anionic site residues are shown as cyan, and the catalytic residue serine 203 is shown as green balls (see Zhang and McCammon).

Image Credit: Image created by David Zhang using VMD v1.8.4.

Message from ISCB

Bioinformatics Education—Perspectives and Challenges

Shoba Ranganathan

PLOS Computational Biology: published November 25, 2005 | https://doi.org/10.1371/journal.pcbi.0010052

Perspective

NIH Roadmap Interdisciplinary Research Initiatives

Michael F Huerta, Gregory K Farber, Elizabeth L Wilder, Dushanka V Kleinman, Patricia A Grady, David A Schwartz, Lawrence A Tabak

PLOS Computational Biology: published November 25, 2005 | https://doi.org/10.1371/journal.pcbi.0010059

Review

Quasispecies Made Simple

J. J Bull, Lauren Ancel Meyers, Michael Lachmann

PLOS Computational Biology: published November 25, 2005 | https://doi.org/10.1371/journal.pcbi.0010061

Research Articles

Genomic Variability within an Organism Exposes Its Cell Lineage Tree

Dan Frumkin, Adam Wasserstrom, Shai Kaplan, Uriel Feige, Ehud Shapiro

PLOS Computational Biology: published October 28, 2005 | https://doi.org/10.1371/journal.pcbi.0010050

Use of Artificial Genomes in Assessing Methods for Atypical Gene Detection

Rajeev K Azad, Jeffrey G Lawrence

PLOS Computational Biology: published November 11, 2005 | https://doi.org/10.1371/journal.pcbi.0010056

A Guild of 45 CRISPR-Associated (Cas) Protein Families and Multiple CRISPR/Cas Subtypes Exist in Prokaryotic Genomes

Daniel H Haft, Jeremy Selengut, Emmanuel F Mongodin, Karen E Nelson

PLOS Computational Biology: published November 11, 2005 | https://doi.org/10.1371/journal.pcbi.0010060

The Association of Tetrameric Acetylcholinesterase with ColQ Tail: A Block Normal Mode Analysis

Deqiang Zhang, J. Andrew McCammon

PLOS Computational Biology: published November 18, 2005 | https://doi.org/10.1371/journal.pcbi.0010062

Stealth Proteins: In Silico Identification of a Novel Protein Family Rendering Bacterial Pathogens Invisible to Host Immune Defense

Peter Sperisen, Christoph D Schmid, Philipp Bucher, Olav Zilian

PLOS Computational Biology: published November 18, 2005 | https://doi.org/10.1371/journal.pcbi.0010063

Quantitative Analysis of Genetic and Neuronal Multi-Perturbation Experiments

Alon Kaufman, Alon Keinan, Isaac Meilijson, Martin Kupiec, Eytan Ruppin

PLOS Computational Biology: published November 25, 2005 | https://doi.org/10.1371/journal.pcbi.0010064

Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis

Thomas LaFramboise, Barbara A Weir, Xiaojun Zhao, Rameen Beroukhim, Cheng Li, David Harrington, William R Sellers, Matthew Meyerson

PLOS Computational Biology: published November 25, 2005 | https://doi.org/10.1371/journal.pcbi.0010065

Refining Protein Subcellular Localization

Michelle S Scott, Sara J Calafell, David Y Thomas, Michael T Hallett

PLOS Computational Biology: published November 25, 2005 | https://doi.org/10.1371/journal.pcbi.0010066

Cover

Model of tetrameric acetylcholinesterase assembled with collagen Q tail