The spatial organization of genomes is highly nonrandom and often exhibits periodic patterns. Shown here is a contour plot that highlights the degree of pattern correlation across multiple genome-scale datasets for Escherichia coli (identified using wavelet analysis). The overlap in these spatial patterns reveals that genome design involves a sophisticated multi-parameter, multi-length scale organization that is not solely dependent upon information content (see Allen et al).
Image Credit: Image generated by Timothy E. Allen using MATLAB software (The MathWorks).
Education
Welcome to PLoS Computational Biology “Education”
PLOS Computational Biology: published January 27, 2006 | https://doi.org/10.1371/journal.pcbi.0020007
Research Articles
Computational Analysis and Prediction of the Binding Motif and Protein Interacting Partners of the Abl SH3 Domain
PLOS Computational Biology: published January 27, 2006 | https://doi.org/10.1371/journal.pcbi.0020001
Long-Range Periodic Patterns in Microbial Genomes Indicate Significant Multi-Scale Chromosomal Organization
PLOS Computational Biology: published January 13, 2006 | https://doi.org/10.1371/journal.pcbi.0020002
Signal Processing in the TGF-β Superfamily Ligand-Receptor Network
PLOS Computational Biology: published January 27, 2006 | https://doi.org/10.1371/journal.pcbi.0020003
Unusual Intron Conservation near Tissue-Regulated Exons Found by Splicing Microarrays
PLOS Computational Biology: published January 20, 2006 | https://doi.org/10.1371/journal.pcbi.0020004
Genome-Wide Identification of Human Functional DNA Using a Neutral Indel Model
PLOS Computational Biology: published January 13, 2006 | https://doi.org/10.1371/journal.pcbi.0020005
Correction
Correction: A Biophysical Model of the Mitochondrial Respiratory System and Oxidative Phosphorylation
PLOS Computational Biology: published January 27, 2006 | https://doi.org/10.1371/journal.pcbi.0020008