The image depicts local fitness environments along an evolutionary path. The surfaces are based on measured data, and show the changes in fitness that can be achieved by a single base pair substitution. The first disc represents a duplicate repressor-operator pair, while the last represents a diverged pair. In this manner, a highly complex, multidimensional fitness landscape can be portrayed. The simulated paths explain why independent protein-DNA interactions can evolve rapidly (see Poelwijk et al).
Image Credit: Created by Frank Poelwijk and Daniel Kiviet using MATLAB, MOLMOL, and Jasc Paint Shop Pro.
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