Subtle structural changes lead to distinct packing of the protein core. These changes appear due to accumulating mutations in the closely related homologous protein families. These random mutations in the ancestor protein (top) can lead to the rearrangement of the protein structure (bottom), which results in the formation of a distinct fold family (see Ding and Dokholyan).
Image Credit: Protein structures visualized with PyMOL software. Design by Nikolay V.
Review
From Functional Genomics to Functional Immunomics: New Challenges, Old Problems, Big Rewards
PLOS Computational Biology: published July 28, 2006 | https://doi.org/10.1371/journal.pcbi.0020081
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Module-Based Analysis of Robustness Tradeoffs in the Heat Shock Response System
PLOS Computational Biology: published July 28, 2006 | https://doi.org/10.1371/journal.pcbi.0020059
Identification of Genome-Scale Metabolic Network Models Using Experimentally Measured Flux Profiles
PLOS Computational Biology: published July 7, 2006 | https://doi.org/10.1371/journal.pcbi.0020072
Systematic Analysis of Head-to-Head Gene Organization: Evolutionary Conservation and Potential Biological Relevance
PLOS Computational Biology: published July 7, 2006 | https://doi.org/10.1371/journal.pcbi.0020074
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Authors' Reply
PLOS Computational Biology: published July 28, 2006 | https://doi.org/10.1371/journal.pcbi.0020083
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