Graphic depiction of a prototypic transcriptional regulatory system (TRS), representative of the Escherichia coli TRS, circumscribing a matrix that would capture the associated regulatory rules. Such a matrix formalism (see Gianchandani et al) enables the calculation of system properties of a TRS.
Image Credit: Image designed by Erwin Gianchandani
Editorial
One Year of PLoS Computational Biology
PLOS Computational Biology: published August 25, 2006 | https://doi.org/10.1371/journal.pcbi.0020111
Message from ISCB
ISCB Honors Michael S. Waterman and Mathieu Blanchette
PLOS Computational Biology: published August 4, 2006 | https://doi.org/10.1371/journal.pcbi.0020105
Review
The Ion Channel Inverse Problem: Neuroinformatics Meets Biophysics
PLOS Computational Biology: published August 25, 2006 | https://doi.org/10.1371/journal.pcbi.0020091
Research Articles
An Integrative Method for Accurate Comparative Genome Mapping
PLOS Computational Biology: published August 4, 2006 | https://doi.org/10.1371/journal.pcbi.0020075
Intrinsic Disorder Is a Common Feature of Hub Proteins from Four Eukaryotic Interactomes
PLOS Computational Biology: published August 4, 2006 | https://doi.org/10.1371/journal.pcbi.0020100
Matrix Formalism to Describe Functional States of Transcriptional Regulatory Systems
PLOS Computational Biology: published August 11, 2006 | https://doi.org/10.1371/journal.pcbi.0020101
Insights into the Coupling of Duplication Events and Macroevolution from an Age Profile of Animal Transmembrane Gene Families
PLOS Computational Biology: published August 11, 2006 | https://doi.org/10.1371/journal.pcbi.0020102
Transient Resetting: A Novel Mechanism for Synchrony and Its Biological Examples
PLOS Computational Biology: published August 4, 2006 | https://doi.org/10.1371/journal.pcbi.0020103
Conservation of Expression and Sequence of Metabolic Genes Is Reflected by Activity Across Metabolic States
PLOS Computational Biology: published August 18, 2006 | https://doi.org/10.1371/journal.pcbi.0020106
Modeling Somatic Evolution in Tumorigenesis
PLOS Computational Biology: published August 18, 2006 | https://doi.org/10.1371/journal.pcbi.0020108
High Epitope Expression Levels Increase Competition between T Cells
PLOS Computational Biology: published August 18, 2006 | https://doi.org/10.1371/journal.pcbi.0020109
Expansion of Protein Domain Repeats
PLOS Computational Biology: published August 25, 2006 | https://doi.org/10.1371/journal.pcbi.0020114
Striking Similarities in the Genomic Distribution of Tandemly Arrayed Genes in Arabidopsis and Rice
PLOS Computational Biology: published September 1, 2006 | https://doi.org/10.1371/journal.pcbi.0020115
Correction
Correction: Systematic Analysis of Head-to-Head Gene Organization: Evolutionary Conservation and Potential Biological Relevance
PLOS Computational Biology: published August 25, 2006 | https://doi.org/10.1371/journal.pcbi.0020112