The modular architecture of type I polyketide synthases allows for truly natural biocombinatorics: creating new compounds very efficiently by recombination of gene segments. Shown here are the phylogenetic relationships of different domain types encoded in the genome of the actinobacterium Streptomyces avermitilis depicting an evolutionary history of extensive recombinational replacements (see Jenke-Kodama et al).
Image Credit: Illustration by Holger Jenke-Kodama
Editorial
Biocurators: Contributors to the World of Science
PLOS Computational Biology: published October 27, 2006 | https://doi.org/10.1371/journal.pcbi.0020142
Perspectives
A Biocurator Perspective: Annotation at the Research Collaboratory for Structural Bioinformatics Protein Data Bank
PLOS Computational Biology: published October 27, 2006 | https://doi.org/10.1371/journal.pcbi.0020099
The Biocurator: Connecting and Enhancing Scientific Data
PLOS Computational Biology: published October 27, 2006 | https://doi.org/10.1371/journal.pcbi.0020125
Research Articles
Simulating Properties of In Vitro Epithelial Cell Morphogenesis
PLOS Computational Biology: published October 6, 2006 | https://doi.org/10.1371/journal.pcbi.0020129
Large-Scale Turnover of Functional Transcription Factor Binding Sites in Drosophila
PLOS Computational Biology: published October 13, 2006 | https://doi.org/10.1371/journal.pcbi.0020130
Natural Biocombinatorics in the Polyketide Synthase Genes of the Actinobacterium Streptomyces avermitilis
PLOS Computational Biology: published October 6, 2006 | https://doi.org/10.1371/journal.pcbi.0020132
Viral and Latent Reservoir Persistence in HIV-1–Infected Patients on Therapy
PLOS Computational Biology: published October 13, 2006 | https://doi.org/10.1371/journal.pcbi.0020135
Quantitative Analyses of Circadian Gene Expression in Mammalian Cell Cultures
PLOS Computational Biology: published October 13, 2006 | https://doi.org/10.1371/journal.pcbi.0020136
The Role of Compensatory Mutations in the Emergence of Drug Resistance
PLOS Computational Biology: published October 13, 2006 | https://doi.org/10.1371/journal.pcbi.0020137
Related Articles
The Transcriptional Regulator CBP Has Defined Spatial Associations within Interphase Nuclei
PLOS Computational Biology: published October 20, 2006 | https://doi.org/10.1371/journal.pcbi.0020139
Cooperation Prevails When Individuals Adjust Their Social Ties
PLOS Computational Biology: published October 20, 2006 | https://doi.org/10.1371/journal.pcbi.0020140
From Bad to Good: Fitness Reversals and the Ascent of Deleterious Mutations
PLOS Computational Biology: published October 20, 2006 | https://doi.org/10.1371/journal.pcbi.0020141
Mapping Information Flow in Sensorimotor Networks
PLOS Computational Biology: published October 27, 2006 | https://doi.org/10.1371/journal.pcbi.0020144
Ab Initio Modeling of the Herpesvirus VP26 Core Domain Assessed by CryoEM Density
PLOS Computational Biology: published October 27, 2006 | https://doi.org/10.1371/journal.pcbi.0020146
Correction
Correction: Emergence of Protein Fold Families through Rational Design
PLOS Computational Biology: published October 27, 2006 | https://doi.org/10.1371/journal.pcbi.0020149