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Table of Contents: October 2006

COVER

Phylogenetic relationships in S. avermitilis

Image Credit: Illustration by Holger Jenke-Kodama
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The modular architecture of type I polyketide synthases allows for truly natural biocombinatorics: creating new compounds very efficiently by recombination of gene segments. Shown here are the phylogenetic relationships of different domain types encoded in the genome of the actinobacterium Streptomyces avermitilis depicting an evolutionary history of extensive recombinational replacements (see Jenke-Kodama et al).

Editorial

Biocurators: Contributors to the World of Science

Philip E Bourne, Johanna McEntyre

Perspectives

Research Articles

Ab Initio Modeling of the Herpesvirus VP26 Core Domain Assessed by CryoEM Density

Matthew L Baker, Wen Jiang, William J Wedemeyer, Frazer J Rixon, David Baker, Wah Chiu

The Transcriptional Regulator CBP Has Defined Spatial Associations within Interphase Nuclei

Kirk J McManus, David A Stephens, Niall M Adams, Suhail A Islam, Paul S Freemont, Michael J Hendzel

Cooperation Prevails When Individuals Adjust Their Social Ties

Francisco C Santos, Jorge M Pacheco, Tom Lenaerts

From Bad to Good: Fitness Reversals and the Ascent of Deleterious Mutations

Matthew C Cowperthwaite, J. J Bull, Lauren Ancel Meyers

Large-Scale Turnover of Functional Transcription Factor Binding Sites in Drosophila

Alan M Moses, Daniel A Pollard, David A Nix, Venky N Iyer, Xiao-Yong Li, Mark D Biggin, Michael B Eisen

Quantitative Analyses of Circadian Gene Expression in Mammalian Cell Cultures

Mariko Izumo, Takashi R Sato, Martin Straume, Carl Hirschie Johnson

Simulating Properties of In Vitro Epithelial Cell Morphogenesis

Mark R Grant, Keith E Mostov, Thea D Tlsty, C. Anthony Hunt

Correction