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Table of Contents: February 2007

COVER

100-ns simulation of a three-component lipid bilayer

Image Credit: Cover design by Perttu Niemelä. Created with the VMD and Raster3D software packages.
Issue Image

Snapshot from the end of a 100-ns simulation of a three-component lipid bilayer: POPC molecules are shown in gray, PSM in orange, CHOL in yellow, and water in cyan. The ratio of different lipids here is POPC:PSM:CHOL = 1:1:1 (see Niemelä et al).

Perspective

From Bytes to Bedside: Data Integration and Computational Biology for Translational Cancer Research

Jomol P Mathew, Barry S Taylor, Gary D Bader, Saiju Pyarajan, Marco Antoniotti, Arul M Chinnaiyan, Chris Sander, Steven J Burakoff, Bud Mishra

Research Articles

Improving the Caenorhabditis elegans Genome Annotation Using Machine Learning

Gunnar Rätsch, Sören Sonnenburg, Jagan Srinivasan, Hanh Witte, Klaus-R Müller, Ralf-J Sommer, Bernhard Schölkopf

Assessing the Nature of Lipid Raft Membranes

Perttu S Niemelä, Samuli Ollila, Marja T Hyvönen, Mikko Karttunen, Ilpo Vattulainen

Functional Impact of Missense Variants in BRCA1 Predicted by Supervised Learning

Rachel Karchin, Alvaro N. A Monteiro, Sean V Tavtigian, Marcelo A Carvalho, Andrej Sali

Synonymous Substitution Rates Predict HIV Disease Progression as a Result of Underlying Replication Dynamics

Philippe Lemey, Sergei L Kosakovsky Pond, Alexei J Drummond, Oliver G Pybus, Beth Shapiro, Helena Barroso, Nuno Taveira, Andrew Rambaut

Corrections

Correction: Inferring Loss-of-Heterozygosity from Unpaired Tumors Using High-Density Oligonucleotide SNP Arrays

Rameen Beroukhim, Ming Lin, Yuhyun Park, Ke Hao, Xiaojun Zhao, Levi A Garraway, Edward A Fox, Ephraim P Hochberg, Ingo K Mellinghoff, Matthias D Hofer, Aurelien Descazeaud, Mark A Rubin, Matthew Meyerson, Wing Hung Wong, William R Sellers, Cheng Li