Sequence changes introduced by alternative splicing and gene duplication are usually different. Shown here is the location and nature (using a hydrophobicity scale) of the differences between alternative splicing isoforms of MAPK9 (left), and between MAPK9 and the paralogs MAPK10 (center) and MAPK13 (right) (see Talavera et al).
Image Credit: Image created by David Talavera, Christine Vogel, and Xavier de la Cruz with PyMOL
Editorial
Ten Simple Rules for a Successful Collaboration
PLOS Computational Biology: published March 30, 2007 | https://doi.org/10.1371/journal.pcbi.0030044
Education
Deciphering Protein–Protein Interactions. Part I. Experimental Techniques and Databases
PLOS Computational Biology: published March 30, 2007 | https://doi.org/10.1371/journal.pcbi.0030042
Research Articles
Dose Response Relationship in Anti-Stress Gene Regulatory Networks
PLOS Computational Biology: published March 2, 2007 | https://doi.org/10.1371/journal.pcbi.0030024
The Stem Cell Population of the Human Colon Crypt: Analysis via Methylation Patterns
PLOS Computational Biology: published March 2, 2007 | https://doi.org/10.1371/journal.pcbi.0030028
PPARα siRNA–Treated Expression Profiles Uncover the Causal Sufficiency Network for Compound-Induced Liver Hypertrophy
PLOS Computational Biology: published March 2, 2007 | https://doi.org/10.1371/journal.pcbi.0030030
The (In)dependence of Alternative Splicing and Gene Duplication
PLOS Computational Biology: published March 2, 2007 | https://doi.org/10.1371/journal.pcbi.0030033
A Mathematical Model for Neutrophil Gradient Sensing and Polarization
PLOS Computational Biology: published March 16, 2007 | https://doi.org/10.1371/journal.pcbi.0030036
Characterization and Identification of MicroRNA Core Promoters in Four Model Species
PLOS Computational Biology: published March 9, 2007 | https://doi.org/10.1371/journal.pcbi.0030037
Spatial Acuity and Prey Detection in Weakly Electric Fish
PLOS Computational Biology: published March 2, 2007 | https://doi.org/10.1371/journal.pcbi.0030038
Discovering Motifs in Ranked Lists of DNA Sequences
PLOS Computational Biology: published March 23, 2007 | https://doi.org/10.1371/journal.pcbi.0030039
UV-Induced Mutagenesis in Escherichia coli SOS Response: A Quantitative Model
PLOS Computational Biology: published March 16, 2007 | https://doi.org/10.1371/journal.pcbi.0030041
Modeling Networks of Coupled Enzymatic Reactions Using the Total Quasi-Steady State Approximation
PLOS Computational Biology: published March 16, 2007 | https://doi.org/10.1371/journal.pcbi.0030045
A Look Inside HIV Resistance through Retroviral Protease Interaction Maps
PLOS Computational Biology: published March 9, 2007 | https://doi.org/10.1371/journal.pcbi.0030048
Measures of Clade Confidence Do Not Correlate with Accuracy of Phylogenetic Trees
PLOS Computational Biology: published March 16, 2007 | https://doi.org/10.1371/journal.pcbi.0030051
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PLOS Computational Biology: published March 16, 2007 | https://doi.org/10.1371/journal.pcbi.0030053
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Correction
Correction: Specificity and Evolvability in Eukaryotic Protein Interaction Networks
PLOS Computational Biology: published March 30, 2007 | https://doi.org/10.1371/journal.pcbi.0030070