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Effect of downregulation
Many signaling receptors are internalized faster when they are bound to their ligand—a phenomenon known as downregulation. The figure shows the effect of downregulation on the response of the epidermal growth factor receptor to time-varying ligand concentrations. Computational analysis reveals that downregulation enhances the accuracy of signaling receptors. (See Shankaran et al, e101).
Image Credit: Figure was made using the MATLAB software.
Messages from ISCB
ISCB Honors Temple F. Smith and Eran Segal
PLOS Computational Biology: published June 29, 2007 | https://doi.org/10.1371/journal.pcbi.0030128
The International Society for Computational Biology 10th Anniversary
PLOS Computational Biology: published June 29, 2007 | https://doi.org/10.1371/journal.pcbi.0030135
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PLOS Computational Biology: published June 29, 2007 | https://doi.org/10.1371/journal.pcbi.0030116
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PLOS Computational Biology: published June 29, 2007 | https://doi.org/10.1371/journal.pcbi.0030105
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