In contrast to biophysical predictions, this image illustrates that "DNA damage sensing proteins" (green signal) form foci along primary cosmic rays in a regular self-excluding manner (see Costes et al, e155). Upper panel: the white dashed arrow indicates the traversal of one Fe particle in a human cell (DNA shown in blue). Middle panel: the relative position of foci (green spheres) is shown with respect to the DNA dye intensity profile visualized by a three-dimensional topographic surface. Lower panel: foci preferentially locate within low DNA nuclear density regions, or at the interface between high and low nuclear DNA densities.
Image Credit: Image by Sylvain Costes.
Education Articles
Recent Evolutions of Multiple Sequence Alignment Algorithms
PLOS Computational Biology: published August 31, 2007 | https://doi.org/10.1371/journal.pcbi.0030123
A Primer on Learning in Bayesian Networks for Computational Biology
PLOS Computational Biology: published August 31, 2007 | https://doi.org/10.1371/journal.pcbi.0030129
Research Articles
Distributed Representations Accelerate Evolution of Adaptive Behaviours
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Automated Discovery of Functional Generality of Human Gene Expression Programs
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SimulFold: Simultaneously Inferring RNA Structures Including Pseudoknots, Alignments, and Trees Using a Bayesian MCMC Framework
PLOS Computational Biology: published August 10, 2007 | https://doi.org/10.1371/journal.pcbi.0030149
Helicobacter pylori Evolution: Lineage- Specific Adaptations in Homologs of Eukaryotic Sel1-Like Genes
PLOS Computational Biology: published August 10, 2007 | https://doi.org/10.1371/journal.pcbi.0030151
An Information-Theoretic Characterization of the Optimal Gradient Sensing Response of Cells
PLOS Computational Biology: published August 3, 2007 | https://doi.org/10.1371/journal.pcbi.0030153
PERIOD–TIMELESS Interval Timer May Require an Additional Feedback Loop
PLOS Computational Biology: published August 3, 2007 | https://doi.org/10.1371/journal.pcbi.0030154
Image-Based Modeling Reveals Dynamic Redistribution of DNA Damage into Nuclear Sub-Domains
PLOS Computational Biology: published August 3, 2007 | https://doi.org/10.1371/journal.pcbi.0030155
Mechanisms of Firing Patterns in Fast-Spiking Cortical Interneurons
PLOS Computational Biology: published August 10, 2007 | https://doi.org/10.1371/journal.pcbi.0030156
On State-Space Reduction in Multi-Strain Pathogen Models, with an Application to Antigenic Drift in Influenza A
PLOS Computational Biology: published August 17, 2007 | https://doi.org/10.1371/journal.pcbi.0030159
Automated Protein Subfamily Identification and Classification
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Elucidating the Altered Transcriptional Programs in Breast Cancer using Independent Component Analysis
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Inferring Function Using Patterns of Native Disorder in Proteins
PLOS Computational Biology: published August 24, 2007 | https://doi.org/10.1371/journal.pcbi.0030162
A Logical Model Provides Insights into T Cell Receptor Signaling
PLOS Computational Biology: published August 24, 2007 | https://doi.org/10.1371/journal.pcbi.0030163
Design of Multi-Specificity in Protein Interfaces
PLOS Computational Biology: published August 24, 2007 | https://doi.org/10.1371/journal.pcbi.0030164
Perceptual Learning via Modification of Cortical Top-Down Signals
PLOS Computational Biology: published August 17, 2007 | https://doi.org/10.1371/journal.pcbi.0030165
Slowness and Sparseness Lead to Place, Head-Direction, and Spatial-View Cells
PLOS Computational Biology: published August 31, 2007 | https://doi.org/10.1371/journal.pcbi.0030166
Functional Representation of Enzymes by Specific Peptides
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A Numerical Approach to Ion Channel Modelling Using Whole-Cell Voltage-Clamp Recordings and a Genetic Algorithm
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Buffering Mechanisms in Aging: A Systems Approach Toward Uncovering the Genetic Component of Aging
PLOS Computational Biology: published August 31, 2007 | https://doi.org/10.1371/journal.pcbi.0030170
Pathway Switching Explains the Sharp Response Characteristic of Hypoxia Response Network
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