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October 2007

A cerebellar-inspired distributed plasticity mechanism is being successfully applied to the adaptive control of the Eye-Robot platform developed by Bristol Robotics Laboratory. This application (supported by the EPSRC Novel Computation Initiative) illustrates the emerging potential for cross-fertilisation between neuroscience and robotics (see Porrill and Dean, e197).

Image Credit: Photograph supplied by Bristol Robotics Laboratory

Editorial

Ten Simple Rules for Doing Your Best Research, According to Hamming

Thomas C Erren, Paul Cullen, Michael Erren, Philip E Bourne

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Messages from ISCB

Perspective

Computational Biology in Brazil

Goran Neshich

Research Articles

Brightness and Darkness as Perceptual Dimensions

Tony Vladusich, Marcel P Lucassen, Frans W Cornelissen

Heat Shock Response in CHO Mammalian Cells Is Controlled by a Nonlinear Stochastic Process

Ovidiu Lipan, Jean-Marc Navenot, Zixuan Wang, Lei Huang, Stephen C Peiper

A Statistical Framework for Modeling HLA-Dependent T Cell Response Data

Jennifer Listgarten, Nicole Frahm, Carl Kadie, Christian Brander, David Heckerman

Universally Sloppy Parameter Sensitivities in Systems Biology Models

Ryan N Gutenkunst, Joshua J Waterfall, Fergal P Casey, Kevin S Brown, Christopher R Myers, James P Sethna

Metabolic Reconstruction and Modeling of Nitrogen Fixation in Rhizobium etli

Osbaldo Resendis-Antonio, Jennifer L Reed, Sergio Encarnación, Julio Collado-Vides, Bernhard Ø Palsson

Fast Pairwise Structural RNA Alignments by Pruning of the Dynamical Programming Matrix

Jakob H Havgaard, Elfar Torarinsson, Jan Gorodkin

Differences in Reactivation of Tuberculosis Induced from Anti-TNF Treatments Are Based on Bioavailability in Granulomatous Tissue

Simeone Marino, Dhruv Sud, Hillarie Plessner, Philana Ling Lin, John Chan, JoAnne L Flynn, Denise E Kirschner

Enzyme Localization Can Drastically Affect Signal Amplification in Signal Transduction Pathways

Siebe B van Albada, Pieter Rein ten Wolde

Alternative Splicing Events Identified in Human Embryonic Stem Cells and Neural Progenitors

Gene W Yeo, Xiangdong Xu, Tiffany Y Liang, Alysson R Muotri, Christian T Carson, Nicole G Coufal, Fred H Gage

Cerebellar Motor Learning: When Is Cortical Plasticity Not Enough?

John Porrill, Paul Dean

Landscape as a Model: The Importance of Geometry

E. Penelope Holland, James N Aegerter, Calvin Dytham, Graham C Smith

A Stochastic View of Spliceosome Assembly and Recycling in the Nucleus

José Rino, Teresa Carvalho, José Braga, Joana M. P Desterro, Reinhard Lührmann, Maria Carmo-Fonseca

Emergence of Recombinant Forms of HIV: Dynamics and Scaling

Gajendra W Suryavanshi, Narendra M Dixit

Construction, Visualisation, and Clustering of Transcription Networks from Microarray Expression Data

Tom C Freeman, Leon Goldovsky, Markus Brosch, Stijn van Dongen, Pierre Mazière, Russell J Grocock, Shiri Freilich, Janet Thornton, Anton J Enright

Empirical Multiscale Networks of Cellular Regulation

Benjamin de Bivort, Sui Huang, Yaneer Bar-Yam