A trinucleotide disease is like a genetic time bomb. A patient with such a disease inherits a DNA region consisting of a three-letter code repeated abnormally many times. The age at which the disease strikes the patient is encoded by the number of repeats. A universal mechanism by which this molecular time bomb operates in this broad family of hereditary diseases has been suggested (see Kaplan et al, e235).
Image Credit: Genia Brodsky, Weizmann Institute of Science
Editorial
Ten Simple Rules for Graduate Students
PLOS Computational Biology: published November 30, 2007 | https://doi.org/10.1371/journal.pcbi.0030229
Education
A Primer on Python for Life Science Researchers
PLOS Computational Biology: published November 30, 2007 | https://doi.org/10.1371/journal.pcbi.0030199
Perspective
Computational Biology in Cuba: An Opportunity to Promote Science in a Developing Country
PLOS Computational Biology: published November 30, 2007 | https://doi.org/10.1371/journal.pcbi.0030227
Research Articles
Phenotypic Mutation Rates and the Abundance of Abnormal Proteins in Yeast
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From Inverse Problems in Mathematical Physiology to Quantitative Differential Diagnoses
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