Table of Contents: January 2008


Structural model of the nicotinic acetylcholine receptor

Image Credit: Picture provided by Xinli Liu. Image created with PyMOL software.
Issue Image

Structural model of the nicotinic acetylcholine receptor (nAChR) embedded in a dipalmitoylphosphatidylcholine (DPPC) bilayer (green) and water molecules (red). Only three subunits (color-coded in red, blue, and yellow) are displayed for clarity. The M2 helices are rendered with electrostatic potential surface to highlight the pore shape (see Liu et al, e19).

Message from ISCB

Getting Started in Text Mining

K. Bretonnel Cohen, Lawrence Hunter


Research Articles

A Quantitative Study of the Division Cycle of Caulobacter crescentus Stalked Cells

Shenghua Li, Paul Brazhnik, Bruno Sobral, John J Tyson

Mechanics of Channel Gating of the Nicotinic Acetylcholine Receptor

Xinli Liu, Yechun Xu, Honglin Li, Xicheng Wang, Hualiang Jiang, Francisco J Barrantes

Co-Regulation of Metabolic Genes Is Better Explained by Flux Coupling Than by Network Distance

Richard A Notebaart, Bas Teusink, Roland J Siezen, Balázs Papp

Why is Real-World Visual Object Recognition Hard?

Nicolas Pinto, David D Cox, James J DiCarlo

In Silico Detection of Sequence Variations Modifying Transcriptional Regulation

Malin C Andersen, Pär G Engström, Stuart Lithwick, David Arenillas, Per Eriksson, Boris Lenhard, Wyeth W Wasserman, Jacob Odeberg

Matt: Local Flexibility Aids Protein Multiple Structure Alignment

Matthew Menke, Bonnie Berger, Lenore Cowen

Genes and (Common) Pathways Underlying Drug Addiction

Chuan-Yun Li, Xizeng Mao, Liping Wei


Coping with Viral Diversity in HIV Vaccine Design: A Response to Nickle et al.

Will Fischer, H. X Liao, Barton F Haynes, Norman L Letvin, Bette Korber

Comparison of Immunogen Designs That Optimize Peptide Coverage: Reply to Fischer et al.

David C Nickle, Nebojsa Jojic, David Heckerman, Vladimir Jojic, Darko Kirovski, Morgane Rolland, Sergei Kosakovsky Pond, James I Mullins