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Table of Contents: June 2008

COVER

Image Credit: Nirav Merchant
Issue Image
Screen capture of data analysis console displaying predicted haplogroup and supporting evidence

The tabular background is values for human Y chromosome microsatellite repeats with the predicted haplogroup for a sample highlighted with a dashed yellow oval. The evolutionary history of the haplogroup is traced in red on the human Y chromosome gene tree; haplogroups traversed during the prediction process and corresponding confidence values are displayed in grey in the lower section of the montage (see Schlecht et al., doi:10.1371/journal.pcbi.1000093).

Editorials

Ten Simple Rules for Organizing a Scientific Meeting

Manuel Corpas, Nils Gehlenborg, Sarath Chandra Janga, Philip E. Bourne

Message from ISCB

ISMB 2008 Toronto

Michal Linial, Jill P. Mesirov, B. J. Morrison McKay, Burkhard Rost

Research Articles

Network Analysis of Intrinsic Functional Brain Connectivity in Alzheimer's Disease

Kaustubh Supekar, Vinod Menon, Daniel Rubin, Mark Musen, Michael D. Greicius

Model-Based Hypothesis Testing of Key Mechanisms in Initial Phase of Insulin Signaling

Gunnar Cedersund, Jacob Roll, Erik Ulfhielm, Anna Danielsson, Henrik Tidefelt, Peter Strålfors

Machine-Learning Approaches for Classifying Haplogroup from Y Chromosome STR Data

Joseph Schlecht, Matthew E. Kaplan, Kobus Barnard, Tatiana Karafet, Michael F. Hammer, Nirav C. Merchant

CSMET: Comparative Genomic Motif Detection via Multi-Resolution Phylogenetic Shadowing

Pradipta Ray, Suyash Shringarpure, Mladen Kolar, Eric P. Xing