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Table of Contents: August 2008

COVER

A model of specific neural assemblies in the insect antennal lobe.

Image Credit: Carlos Hurtado and Dominique Martinez
Issue Image

Inhibitory local neurons (LNs) receive inputs from olfactory glomeruli. Consequently, stimulus patterns activate specific inhibitory sub-circuits (only a few connections are displayed for clarity). In the model of Martinez and Montejo (see Martinez and Montejo, doi:10.1371/journal.pcbi.1000139), the relative number between fast GABAA and slow GABAB inputs regulates synchrony and determines whether particular projection neurons engage in the neural assembly (synchronized neurons are colored in black).

Editorial

Message from ISCB

Perspective

Review

The Dynamic Brain: From Spiking Neurons to Neural Masses and Cortical Fields

Gustavo Deco, Viktor K. Jirsa, Peter A. Robinson, Michael Breakspear, Karl Friston

Research Articles

Biophysical Parameters Modification Could Overcome Essential Hearing Gaps

A. Kern, C. Heid, W.-H. Steeb, N. Stoop, R. Stoop

Network Inference Algorithms Elucidate Nrf2 Regulation of Mouse Lung Oxidative Stress

Ronald C. Taylor, George Acquaah-Mensah, Mudita Singhal, Deepti Malhotra, Shyam Biswal

Noise Reduction by Diffusional Dissipation in a Minimal Quorum Sensing Motif

Yu Tanouchi, Dennis Tu, Jungsang Kim, Lingchong You

Stroke Rehabilitation Reaches a Threshold

Cheol E. Han, Michael A. Arbib, Nicolas Schweighofer

Predicting Human Nucleosome Occupancy from Primary Sequence

Shobhit Gupta, Jonathan Dennis, Robert E. Thurman, Robert Kingston, John A. Stamatoyannopoulos, William Stafford Noble

Modeling ChIP Sequencing In Silico with Applications

Zhengdong D. Zhang, Joel Rozowsky, Michael Snyder, Joseph Chang, Mark Gerstein

Regulatory Control and the Costs and Benefits of Biochemical Noise

Sorin Tănase-Nicola, Pieter Rein ten Wolde

Efficient Algorithms for Probing the RNA Mutation Landscape

Jérôme Waldispühl, Srinivas Devadas, Bonnie Berger, Peter Clote

Intramolecular Cohesion of Coils Mediated by Phenylalanine–Glycine Motifs in the Natively Unfolded Domain of a Nucleoporin

V. V. Krishnan, Edmond Y. Lau, Justin Yamada, Daniel P. Denning, Samir S. Patel, Michael E. Colvin, Michael F. Rexach

A General Definition and Nomenclature for Alternative Splicing Events

Michael Sammeth, Sylvain Foissac, Roderic Guigó

Innate Visual Learning through Spontaneous Activity Patterns

Mark V. Albert, Adam Schnabel, David J. Field

Identification and Rational Redesign of Peptide Ligands to CRIP1, A Novel Biomarker for Cancers

Jihua Hao, Adrian W. R. Serohijos, Gail Newton, Gina Tassone, Zuncai Wang, Dennis C. Sgroi, Nikolay V. Dokholyan, James P. Basilion

Embedding mRNA Stability in Correlation Analysis of Time-Series Gene Expression Data

Lorenzo Farina, Alberto De Santis, Samanta Salvucci, Giorgio Morelli, Ida Ruberti