Antibiotics have been the mainstay of treatment for a variety of infectious diseases such as pneumonia. Due to the increasing incidence of antimicrobial resistance, we are at risk of returning to the pre-antibiotic era, and the need to develop new drugs rapidly is becoming more urgent. A new computational method could provide quantitative insights to the interaction between an antimicrobial agent and a pathogen, which would facilitate new agent development by rationally guiding selection of dosing regimens. (See Tam and Nikolau, doi:10.1371/journal.pcbi.1001043.)
Image Credit: Thomas Shea, University of Houston Cullen College of Engineering
Editorials
A Review of 2010 for PLoS Computational Biology
PLOS Computational Biology: published January 27, 2011 | https://doi.org/10.1371/journal.pcbi.1002003
Ten Simple Rules for Getting Ahead as a Computational Biologist in Academia
PLOS Computational Biology: published January 6, 2011 | https://doi.org/10.1371/journal.pcbi.1002001
Research Articles
Detecting Remote Evolutionary Relationships among Proteins by Large-Scale Semantic Embedding
PLOS Computational Biology: published January 27, 2011 | https://doi.org/10.1371/journal.pcbi.1001047
Estimation of Parent Specific DNA Copy Number in Tumors using High-Density Genotyping Arrays
PLOS Computational Biology: published January 27, 2011 | https://doi.org/10.1371/journal.pcbi.1001060
Erratic Flu Vaccination Emerges from Short-Sighted Behavior in Contact Networks
PLOS Computational Biology: published January 27, 2011 | https://doi.org/10.1371/journal.pcbi.1001062
The Role of Additive Neurogenesis and Synaptic Plasticity in a Hippocampal Memory Model with Grid-Cell Like Input
PLOS Computational Biology: published January 27, 2011 | https://doi.org/10.1371/journal.pcbi.1001063
Integrative Features of the Yeast Phosphoproteome and Protein–Protein Interaction Map
PLOS Computational Biology: published January 27, 2011 | https://doi.org/10.1371/journal.pcbi.1001064
Impact of Sarcoplasmic Reticulum Calcium Release on Calcium Dynamics and Action Potential Morphology in Human Atrial Myocytes: A Computational Study
PLOS Computational Biology: published January 27, 2011 | https://doi.org/10.1371/journal.pcbi.1001067
Protrusive Push versus Enveloping Embrace: Computational Model of Phagocytosis Predicts Key Regulatory Role of Cytoskeletal Membrane Anchors
PLOS Computational Biology: published January 27, 2011 | https://doi.org/10.1371/journal.pcbi.1001068
Risk, Unexpected Uncertainty, and Estimation Uncertainty: Bayesian Learning in Unstable Settings
PLOS Computational Biology: published January 20, 2011 | https://doi.org/10.1371/journal.pcbi.1001048
Theoretical Analysis of the Stress Induced B-Z Transition in Superhelical DNA
PLOS Computational Biology: published January 20, 2011 | https://doi.org/10.1371/journal.pcbi.1001051
Practical Measures of Integrated Information for Time-Series Data
PLOS Computational Biology: published January 20, 2011 | https://doi.org/10.1371/journal.pcbi.1001052
From Spiking Neuron Models to Linear-Nonlinear Models
PLOS Computational Biology: published January 20, 2011 | https://doi.org/10.1371/journal.pcbi.1001056
Is My Network Module Preserved and Reproducible?
PLOS Computational Biology: published January 20, 2011 | https://doi.org/10.1371/journal.pcbi.1001057
A Computational and Experimental Study of the Regulatory Mechanisms of the Complement System
PLOS Computational Biology: published January 20, 2011 | https://doi.org/10.1371/journal.pcbi.1001059
PhylOTU: A High-Throughput Procedure Quantifies Microbial Community Diversity and Resolves Novel Taxa from Metagenomic Data
PLOS Computational Biology: published January 20, 2011 | https://doi.org/10.1371/journal.pcbi.1001061
Benchmarking Ontologies: Bigger or Better?
PLOS Computational Biology: published January 13, 2011 | https://doi.org/10.1371/journal.pcbi.1001055
Thermodynamic Stability of Histone H3 Is a Necessary but not Sufficient Driving Force for its Evolutionary Conservation
PLOS Computational Biology: published January 6, 2011 | https://doi.org/10.1371/journal.pcbi.1001042
A Novel Approach to Pharmacodynamic Assessment of Antimicrobial Agents: New Insights to Dosing Regimen Design
PLOS Computational Biology: published January 6, 2011 | https://doi.org/10.1371/journal.pcbi.1001043
Neural Development Features: Spatio-Temporal Development of the Caenorhabditis elegans Neuronal Network
PLOS Computational Biology: published January 6, 2011 | https://doi.org/10.1371/journal.pcbi.1001044
A Comprehensive Model of the Spatio-Temporal Stem Cell and Tissue Organisation in the Intestinal Crypt
PLOS Computational Biology: published January 6, 2011 | https://doi.org/10.1371/journal.pcbi.1001045
Decrypting the Sequence of Structural Events during the Gating Transition of Pentameric Ligand-Gated Ion Channels Based on an Interpolated Elastic Network Model
PLOS Computational Biology: published January 6, 2011 | https://doi.org/10.1371/journal.pcbi.1001046
Relationships between Gene Expression and Brain Wiring in the Adult Rodent Brain
PLOS Computational Biology: published January 6, 2011 | https://doi.org/10.1371/journal.pcbi.1001049
Measuring the Evolutionary Rewiring of Biological Networks
PLOS Computational Biology: published January 6, 2011 | https://doi.org/10.1371/journal.pcbi.1001050
Predicting Novel Binding Modes of Agonists to β Adrenergic Receptors Using All-Atom Molecular Dynamics Simulations
PLOS Computational Biology: published January 6, 2011 | https://doi.org/10.1371/journal.pcbi.1001053
Using Transcription Modules to Identify Expression Clusters Perturbed in Williams-Beuren Syndrome
PLOS Computational Biology: published January 20, 2011 | https://doi.org/10.1371/journal.pcbi.1001054