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Table of Contents: April 2011

COVER

A model of the morphology of the rat vibrissal array.

Image Credit: Brian Quist, Northwestern University
Issue Image

The rat vibrissal system provides an ideal model to examine how the physical embodiment of a sensory array shapes the sensing process. We quantified the morphology of the rat vibrissal array to develop a model that can be used to simulate the spatiotemporal patterns of vibrissa—object contact during tactile exploratory behavior (see Towal et al. doi:10.1371/journal.pcbi.1001120). The left half of the image illustrates the vibrissal array of a real rat, and the right half illustrates the model.

Perspective

Minimum Information About a Simulation Experiment (MIASE)

Dagmar Waltemath, Richard Adams, Daniel A. Beard, Frank T. Bergmann, Upinder S. Bhalla, Randall Britten, Vijayalakshmi Chelliah, Michael T. Cooling, Jonathan Cooper, Edmund J. Crampin, Alan Garny, Stefan Hoops, Michael Hucka, Peter Hunter, Edda Klipp, Camille Laibe, Andrew K. Miller, Ion Moraru, David Nickerson, Poul Nielsen, Macha Nikolski, Sven Sahle, Herbert M. Sauro, Henning Schmidt, Jacky L. Snoep, Dominic Tolle, Olaf Wolkenhauer, Nicolas Le Novère

Review

Research Articles

Disentangling the Roles of Approach, Activation and Valence in Instrumental and Pavlovian Responding

Quentin J. M. Huys, Roshan Cools, Martin Gölzer, Eva Friedel, Andreas Heinz, Raymond J. Dolan, Peter Dayan

Accessing a Hidden Conformation of the Maltose Binding Protein Using Accelerated Molecular Dynamics

Denis Bucher, Barry J. Grant, Phineus R. Markwick, J. Andrew McCammon

Discovering Biological Progression Underlying Microarray Samples

Peng Qiu, Andrew J. Gentles, Sylvia K. Plevritis

The Morphology of the Rat Vibrissal Array: A Model for Quantifying Spatiotemporal Patterns of Whisker-Object Contact

R. Blythe Towal, Brian W. Quist, Venkatesh Gopal, Joseph H. Solomon, Mitra J. Z. Hartmann

Cell-Sorting at the A/P Boundary in the Drosophila Wing Primordium: A Computational Model to Consolidate Observed Non-Local Effects of Hh Signaling

Sabine Schilling, Maria Willecke, Tinri Aegerter-Wilmsen, Olaf A. Cirpka, Konrad Basler, Christian von Mering

MDCK Cystogenesis Driven by Cell Stabilization within Computational Analogues

Jesse A. Engelberg, Anirban Datta, Keith E. Mostov, C. Anthony Hunt