In the top right image the simulated methylation patterns in a nonhierarchical (classical) malignancy, indicated with different colors, radiate outward from the center. In the bottom left image, in contrast, the patterns occurring in a hierarchical (CSC-driven) tumor spread as patch-like colonies, increasing the overall intratumor heterogeneity and greatly affecting the evolutionary properties of the cancer cell population. (See Sottoriva et al., doi: 10.1371/journal.pcbi.1001132)
Image Credit: Andrea Sottoriva, Cambridge University, United Kingdom
Editorial
Ten Simple Rules for Providing a Scientific Web Resource
PLOS Computational Biology: published May 26, 2011 | https://doi.org/10.1371/journal.pcbi.1001126
Education
Pathway Analysis of Expression Data: Deciphering Functional Building Blocks of Complex Diseases
PLOS Computational Biology: published May 26, 2011 | https://doi.org/10.1371/journal.pcbi.1002053
Research Articles
How Modeling Can Reconcile Apparently Discrepant Experimental Results: The Case of Pacemaking in Dopaminergic Neurons
PLOS Computational Biology: published May 26, 2011 | https://doi.org/10.1371/journal.pcbi.1002050
A Role for Both Conformational Selection and Induced Fit in Ligand Binding by the LAO Protein
PLOS Computational Biology: published May 26, 2011 | https://doi.org/10.1371/journal.pcbi.1002054
Speed/Accuracy Trade-Off between the Habitual and the Goal-Directed Processes
PLOS Computational Biology: published May 26, 2011 | https://doi.org/10.1371/journal.pcbi.1002055
An Acidic Loop and Cognate Phosphorylation Sites Define a Molecular Switch That Modulates Ubiquitin Charging Activity in Cdc34-Like Enzymes
PLOS Computational Biology: published May 26, 2011 | https://doi.org/10.1371/journal.pcbi.1002056
Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation
PLOS Computational Biology: published May 26, 2011 | https://doi.org/10.1371/journal.pcbi.1002061
A Toolbox Model of Evolution of Metabolic Pathways on Networks of Arbitrary Topology
PLOS Computational Biology: published May 19, 2011 | https://doi.org/10.1371/journal.pcbi.1001137
deFuse: An Algorithm for Gene Fusion Discovery in Tumor RNA-Seq Data
PLOS Computational Biology: published May 19, 2011 | https://doi.org/10.1371/journal.pcbi.1001138
Topological Cluster Analysis Reveals the Systemic Organization of the Caenorhabditis elegans Connectome
PLOS Computational Biology: published May 19, 2011 | https://doi.org/10.1371/journal.pcbi.1001139
Spatial Learning and Action Planning in a Prefrontal Cortical Network Model
PLOS Computational Biology: published May 19, 2011 | https://doi.org/10.1371/journal.pcbi.1002045
Integrative Analysis of Transgenic Alfalfa (Medicago sativa L.) Suggests New Metabolic Control Mechanisms for Monolignol Biosynthesis
PLOS Computational Biology: published May 19, 2011 | https://doi.org/10.1371/journal.pcbi.1002047
A Multiscale Approach to Characterize the Early Aggregation Steps of the Amyloid-Forming Peptide GNNQQNY from the Yeast Prion Sup-35
PLOS Computational Biology: published May 19, 2011 | https://doi.org/10.1371/journal.pcbi.1002051
Attracting Dynamics of Frontal Cortex Ensembles during Memory-Guided Decision-Making
PLOS Computational Biology: published May 19, 2011 | https://doi.org/10.1371/journal.pcbi.1002057
How Structure Determines Correlations in Neuronal Networks
PLOS Computational Biology: published May 19, 2011 | https://doi.org/10.1371/journal.pcbi.1002059
Cellularly-Driven Differences in Network Synchronization Propensity Are Differentially Modulated by Firing Frequency
PLOS Computational Biology: published May 19, 2011 | https://doi.org/10.1371/journal.pcbi.1002062
An Imperfect Dopaminergic Error Signal Can Drive Temporal-Difference Learning
PLOS Computational Biology: published May 12, 2011 | https://doi.org/10.1371/journal.pcbi.1001133
Epistasis in a Model of Molecular Signal Transduction
PLOS Computational Biology: published May 12, 2011 | https://doi.org/10.1371/journal.pcbi.1001134
Transcriptional Regulation: Effects of Promoter Proximal Pausing on Speed, Synchrony and Reliability
PLOS Computational Biology: published May 12, 2011 | https://doi.org/10.1371/journal.pcbi.1001136
Exhaustive Sampling of Docking Poses Reveals Binding Hypotheses for Propafenone Type Inhibitors of P-Glycoprotein
PLOS Computational Biology: published May 12, 2011 | https://doi.org/10.1371/journal.pcbi.1002036
Emergence of Switch-Like Behavior in a Large Family of Simple Biochemical Networks
PLOS Computational Biology: published May 12, 2011 | https://doi.org/10.1371/journal.pcbi.1002039
Quantitative Epistasis Analysis and Pathway Inference from Genetic Interaction Data
PLOS Computational Biology: published May 12, 2011 | https://doi.org/10.1371/journal.pcbi.1002048
Theoretical Model for Cellular Shapes Driven by Protrusive and Adhesive Forces
PLOS Computational Biology: published May 5, 2011 | https://doi.org/10.1371/journal.pcbi.1001127
Simulating the Mammalian Blastocyst - Molecular and Mechanical Interactions Pattern the Embryo
PLOS Computational Biology: published May 5, 2011 | https://doi.org/10.1371/journal.pcbi.1001128
Impact of Fast Sodium Channel Inactivation on Spike Threshold Dynamics and Synaptic Integration
PLOS Computational Biology: published May 5, 2011 | https://doi.org/10.1371/journal.pcbi.1001129
Feedback Control Architecture and the Bacterial Chemotaxis Network
PLOS Computational Biology: published May 5, 2011 | https://doi.org/10.1371/journal.pcbi.1001130
Detecting Network Communities: An Application to Phylogenetic Analysis
PLOS Computational Biology: published May 5, 2011 | https://doi.org/10.1371/journal.pcbi.1001131
Modeling Evolutionary Dynamics of Epigenetic Mutations in Hierarchically Organized Tumors
PLOS Computational Biology: published May 5, 2011 | https://doi.org/10.1371/journal.pcbi.1001132
Identification of Hammerhead Ribozymes in All Domains of Life Reveals Novel Structural Variations
PLOS Computational Biology: published May 5, 2011 | https://doi.org/10.1371/journal.pcbi.1002031
How Molecular Motors Are Arranged on a Cargo Is Important for Vesicular Transport
PLOS Computational Biology: published May 5, 2011 | https://doi.org/10.1371/journal.pcbi.1002032
Gene Expression in the Rodent Brain is Associated with Its Regional Connectivity
PLOS Computational Biology: published May 5, 2011 | https://doi.org/10.1371/journal.pcbi.1002040
Temporal Encoding in a Nervous System
PLOS Computational Biology: published May 5, 2011 | https://doi.org/10.1371/journal.pcbi.1002041
Combinations of Protein-Chemical Complex Structures Reveal New Targets for Established Drugs
PLOS Computational Biology: published May 5, 2011 | https://doi.org/10.1371/journal.pcbi.1002043
Distributions of Transposable Elements Reveal Hazardous Zones in Mammalian Introns
PLOS Computational Biology: published May 5, 2011 | https://doi.org/10.1371/journal.pcbi.1002046