Pictured are two biomolecular networks from budding yeast, composed of different basic architectures. The generalized time-frequency analysis framework developed by Ratushny et al. enables the systematic exploration of the dynamical properties of biomolecular networks. Using this framework, the authors reveal remarkably distinct network behaviors in terms of trade-offs between responsiveness and noise suppression that are appropriately tuned to each biological response. (See Ratushny et al., doi: 10.1371/journal.pcbi.1002091)
Image Credit: Alexander V. Ratushny, Institute for Systems Biology, USA.
Editorial
Ten Simple Rules for Building and Maintaining a Scientific Reputation
PLOS Computational Biology: published June 30, 2011 | https://doi.org/10.1371/journal.pcbi.1002108
Message from ISCB
International Society for Computational Biology Honors Michael Ashburner and Olga Troyanskaya with Top Bioinformatics/Computational Biology Awards for 2011
PLOS Computational Biology: published June 2, 2011 | https://doi.org/10.1371/journal.pcbi.1002081
Perspectives
The Development of Computational Biology in Pakistan: Still a Long Way to Go
PLOS Computational Biology: published June 30, 2011 | https://doi.org/10.1371/journal.pcbi.1001135
Eurekometrics: Analyzing the Nature of Discovery
PLOS Computational Biology: published June 30, 2011 | https://doi.org/10.1371/journal.pcbi.1002072
Research Articles
Activated Membrane Patches Guide Chemotactic Cell Motility
PLOS Computational Biology: published June 30, 2011 | https://doi.org/10.1371/journal.pcbi.1002044
Differential Producibility Analysis (DPA) of Transcriptomic Data with Metabolic Networks: Deconstructing the Metabolic Response of M. tuberculosis
PLOS Computational Biology: published June 30, 2011 | https://doi.org/10.1371/journal.pcbi.1002060
Learning, Memory, and the Role of Neural Network Architecture
PLOS Computational Biology: published June 30, 2011 | https://doi.org/10.1371/journal.pcbi.1002063
Construction and Modelling of an Inducible Positive Feedback Loop Stably Integrated in a Mammalian Cell-Line
PLOS Computational Biology: published June 30, 2011 | https://doi.org/10.1371/journal.pcbi.1002074
How Haptic Size Sensations Improve Distance Perception
PLOS Computational Biology: published June 30, 2011 | https://doi.org/10.1371/journal.pcbi.1002080
Colocalization of Protein Kinase A with Adenylyl Cyclase Enhances Protein Kinase A Activity during Induction of Long-Lasting Long-Term-Potentiation
PLOS Computational Biology: published June 30, 2011 | https://doi.org/10.1371/journal.pcbi.1002084
Trade-off between Responsiveness and Noise Suppression in Biomolecular System Responses to Environmental Cues
PLOS Computational Biology: published June 30, 2011 | https://doi.org/10.1371/journal.pcbi.1002091
Spatio-Temporal Credit Assignment in Neuronal Population Learning
PLOS Computational Biology: published June 30, 2011 | https://doi.org/10.1371/journal.pcbi.1002092
Network Clustering Revealed the Systemic Alterations of Mitochondrial Protein Expression
PLOS Computational Biology: published June 30, 2011 | https://doi.org/10.1371/journal.pcbi.1002093
Partially Glycosylated Dendrimers Block MD-2 and Prevent TLR4-MD-2-LPS Complex Mediated Cytokine Responses
PLOS Computational Biology: published June 30, 2011 | https://doi.org/10.1371/journal.pcbi.1002095
Heterogeneous Host Susceptibility Enhances Prevalence of Mixed-Genotype Micro-Parasite Infections
PLOS Computational Biology: published June 30, 2011 | https://doi.org/10.1371/journal.pcbi.1002097
Computational Investigation of the Changing Patterns of Subtype Specific NMDA Receptor Activation during Physiological Glutamatergic Neurotransmission
PLOS Computational Biology: published June 30, 2011 | https://doi.org/10.1371/journal.pcbi.1002106
The Binding of Learning to Action in Motor Adaptation
PLOS Computational Biology: published June 23, 2011 | https://doi.org/10.1371/journal.pcbi.1002052
Dynamic Structure Formation of Peripheral Membrane Proteins
PLOS Computational Biology: published June 23, 2011 | https://doi.org/10.1371/journal.pcbi.1002067
The Origin of Behavioral Bursts in Decision-Making Circuitry
PLOS Computational Biology: published June 23, 2011 | https://doi.org/10.1371/journal.pcbi.1002075
Generative Embedding for Model-Based Classification of fMRI Data
PLOS Computational Biology: published June 23, 2011 | https://doi.org/10.1371/journal.pcbi.1002079
Predicting Binding to P-Glycoprotein by Flexible Receptor Docking
PLOS Computational Biology: published June 23, 2011 | https://doi.org/10.1371/journal.pcbi.1002083
Robust Network Topologies for Generating Switch-Like Cellular Responses
PLOS Computational Biology: published June 23, 2011 | https://doi.org/10.1371/journal.pcbi.1002085
Changes of Mind in an Attractor Network of Decision-Making
PLOS Computational Biology: published June 23, 2011 | https://doi.org/10.1371/journal.pcbi.1002086
An Evolutionary Trade-Off between Protein Turnover Rate and Protein Aggregation Favors a Higher Aggregation Propensity in Fast Degrading Proteins
PLOS Computational Biology: published June 23, 2011 | https://doi.org/10.1371/journal.pcbi.1002090
Integrative Analysis of Many Weighted Co-Expression Networks Using Tensor Computation
PLOS Computational Biology: published June 16, 2011 | https://doi.org/10.1371/journal.pcbi.1001106
Impact of Microscopic Motility on the Swimming Behavior of Parasites: Straighter Trypanosomes are More Directional
PLOS Computational Biology: published June 16, 2011 | https://doi.org/10.1371/journal.pcbi.1002058
Mutation D816V Alters the Internal Structure and Dynamics of c-KIT Receptor Cytoplasmic Region: Implications for Dimerization and Activation Mechanisms
PLOS Computational Biology: published June 16, 2011 | https://doi.org/10.1371/journal.pcbi.1002068
Bayesian Comparison of Neurovascular Coupling Models Using EEG-fMRI
PLOS Computational Biology: published June 16, 2011 | https://doi.org/10.1371/journal.pcbi.1002070
Generation of Diverse Biological Forms through Combinatorial Interactions between Tissue Polarity and Growth
PLOS Computational Biology: published June 16, 2011 | https://doi.org/10.1371/journal.pcbi.1002071
The Role of Response Elements Organization in Transcription Factor Selectivity: The IFN-β Enhanceosome Example
PLOS Computational Biology: published June 16, 2011 | https://doi.org/10.1371/journal.pcbi.1002077
Towards an Evolutionary Model of Transcription Networks
PLOS Computational Biology: published June 9, 2011 | https://doi.org/10.1371/journal.pcbi.1002064
A New View of the Bacterial Cytosol Environment
PLOS Computational Biology: published June 9, 2011 | https://doi.org/10.1371/journal.pcbi.1002066
Mutual Inactivation of Notch Receptors and Ligands Facilitates Developmental Patterning
PLOS Computational Biology: published June 9, 2011 | https://doi.org/10.1371/journal.pcbi.1002069
Testing the Ortholog Conjecture with Comparative Functional Genomic Data from Mammals
PLOS Computational Biology: published June 9, 2011 | https://doi.org/10.1371/journal.pcbi.1002073
Neurobiologically Realistic Determinants of Self-Organized Criticality in Networks of Spiking Neurons
PLOS Computational Biology: published June 2, 2011 | https://doi.org/10.1371/journal.pcbi.1002038
Effects of Heterogeneous and Clustered Contact Patterns on Infectious Disease Dynamics
PLOS Computational Biology: published June 2, 2011 | https://doi.org/10.1371/journal.pcbi.1002042
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