Neocortical L5 pyramidal cells generate dendritic Ca2+ spikes in distal apical region (top red region and corresponding voltage trace) as well as Na+ spikes in perisomatic region (bottom red region and voltage trace). The two spiking zones interact electrically in a complex "ping-pong"-like manner. This study provides detailed conductance-based models that faithfully replicate these important spiking properties together with their variability, as measured experimentally. This was achieved using multi-objective evolutionary optimization algorithm and experimentally measured statistics of both Ca2+ and Na+ spiking features. The study highlights the candidate key biophysical mechanisms underlying these active electrical properties of L5 pyramidal cells. (see Hay et al., doi:10.1371/journal.pcbi.1002107).
Image Credit: Ariel Chai, Brisbane, Australia
Review
Bridging the Resolution Gap in Structural Modeling of 3D Genome Organization
PLOS Computational Biology: published July 14, 2011 | https://doi.org/10.1371/journal.pcbi.1002125
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