The correct regeneration of complex morphology after amputation in planaria requires precise coordination of global patterning information and individual stem cell activity. This image illustrates the algorithmic information that is processed by cells and tissues to restore missing structures. See Lobo and Beane(e1002281).
Image Credit: Image produced by Daniel Lobo and Wendy Beane.
Perspective
Modeling Planarian Regeneration: A Primer for Reverse-Engineering the Worm
PLOS Computational Biology: published April 26, 2012 | https://doi.org/10.1371/journal.pcbi.1002481
Review
Rise and Demise of Bioinformatics? Promise and Progress
PLOS Computational Biology: published April 26, 2012 | https://doi.org/10.1371/journal.pcbi.1002487
Research Articles
Storage of Correlated Patterns in Standard and Bistable Purkinje Cell Models
PLOS Computational Biology: published April 26, 2012 | https://doi.org/10.1371/journal.pcbi.1002448
Deconvolution of the Cellular Force-Generating Subsystems that Govern Cytokinesis Furrow Ingression
PLOS Computational Biology: published April 26, 2012 | https://doi.org/10.1371/journal.pcbi.1002467
Determinants of Sexual Network Structure and Their Impact on Cumulative Network Measures
PLOS Computational Biology: published April 26, 2012 | https://doi.org/10.1371/journal.pcbi.1002470
Exploring the Contextual Sensitivity of Factors that Determine Cell-to-Cell Variability in Receptor-Mediated Apoptosis
PLOS Computational Biology: published April 26, 2012 | https://doi.org/10.1371/journal.pcbi.1002482
Testing Biochemistry Revisited: How In Vivo Metabolism Can Be Understood from In Vitro Enzyme Kinetics
PLOS Computational Biology: published April 26, 2012 | https://doi.org/10.1371/journal.pcbi.1002483
Theoretical Analysis of Competing Conformational Transitions in Superhelical DNA
PLOS Computational Biology: published April 26, 2012 | https://doi.org/10.1371/journal.pcbi.1002484
Microarray Analysis of LTR Retrotransposon Silencing Identifies Hdac1 as a Regulator of Retrotransposon Expression in Mouse Embryonic Stem Cells
PLOS Computational Biology: published April 26, 2012 | https://doi.org/10.1371/journal.pcbi.1002486
Predictive Features of Persistent Activity Emergence in Regular Spiking and Intrinsic Bursting Model Neurons
PLOS Computational Biology: published April 26, 2012 | https://doi.org/10.1371/journal.pcbi.1002489
Tension and Robustness in Multitasking Cellular Networks
PLOS Computational Biology: published April 26, 2012 | https://doi.org/10.1371/journal.pcbi.1002491
Social Interaction, Noise and Antibiotic-Mediated Switches in the Intestinal Microbiota
PLOS Computational Biology: published April 26, 2012 | https://doi.org/10.1371/journal.pcbi.1002497
Are Long-Range Structural Correlations Behind the Aggregration Phenomena of Polyglutamine Diseases?
PLOS Computational Biology: published April 26, 2012 | https://doi.org/10.1371/journal.pcbi.1002501
Non-Additive Coupling Enables Propagation of Synchronous Spiking Activity in Purely Random Networks
PLOS Computational Biology: published April 19, 2012 | https://doi.org/10.1371/journal.pcbi.1002384
The Emergence and Early Evolution of Biological Carbon-Fixation
PLOS Computational Biology: published April 19, 2012 | https://doi.org/10.1371/journal.pcbi.1002455
Exploration of Multi-State Conformational Dynamics and Underlying Global Functional Landscape of Maltose Binding Protein
PLOS Computational Biology: published April 19, 2012 | https://doi.org/10.1371/journal.pcbi.1002471
Ligand-Dependent Conformations and Dynamics of the Serotonin 5-HT2A Receptor Determine Its Activation and Membrane-Driven Oligomerization Properties
PLOS Computational Biology: published April 19, 2012 | https://doi.org/10.1371/journal.pcbi.1002473
Persisting Viral Sequences Shape Microbial CRISPR-based Immunity
PLOS Computational Biology: published April 19, 2012 | https://doi.org/10.1371/journal.pcbi.1002475
Computational Design of a PDZ Domain Peptide Inhibitor that Rescues CFTR Activity
PLOS Computational Biology: published April 19, 2012 | https://doi.org/10.1371/journal.pcbi.1002477
Inference of Genotype–Phenotype Relationships in the Antigenic Evolution of Human Influenza A (H3N2) Viruses
PLOS Computational Biology: published April 19, 2012 | https://doi.org/10.1371/journal.pcbi.1002492
The Effects of NMDA Subunit Composition on Calcium Influx and Spike Timing-Dependent Plasticity in Striatal Medium Spiny Neurons
PLOS Computational Biology: published April 19, 2012 | https://doi.org/10.1371/journal.pcbi.1002493
Evolution of the Multi-Domain Structures of Virulence Genes in the Human Malaria Parasite, Plasmodium falciparum
PLOS Computational Biology: published April 12, 2012 | https://doi.org/10.1371/journal.pcbi.1002451
A New Perceptual Bias Reveals Suboptimal Population Decoding of Sensory Responses
PLOS Computational Biology: published April 12, 2012 | https://doi.org/10.1371/journal.pcbi.1002453
Quantifying Type-Specific Reproduction Numbers for Nosocomial Pathogens: Evidence for Heightened Transmission of an Asian Sequence Type 239 MRSA Clone
PLOS Computational Biology: published April 12, 2012 | https://doi.org/10.1371/journal.pcbi.1002454
Warm Body Temperature Facilitates Energy Efficient Cortical Action Potentials
PLOS Computational Biology: published April 12, 2012 | https://doi.org/10.1371/journal.pcbi.1002456
Power-Law Inter-Spike Interval Distributions Infer a Conditional Maximization of Entropy in Cortical Neurons
PLOS Computational Biology: published April 12, 2012 | https://doi.org/10.1371/journal.pcbi.1002461
Optimization of Muscle Activity for Task-Level Goals Predicts Complex Changes in Limb Forces across Biomechanical Contexts
PLOS Computational Biology: published April 12, 2012 | https://doi.org/10.1371/journal.pcbi.1002465
Differences in Cell Division Rates Drive the Evolution of Terminal Differentiation in Microbes
PLOS Computational Biology: published April 12, 2012 | https://doi.org/10.1371/journal.pcbi.1002468
Related Articles
The Impact of Imitation on Vaccination Behavior in Social Contact Networks
PLOS Computational Biology: published April 12, 2012 | https://doi.org/10.1371/journal.pcbi.1002469
Optimizing Provider Recruitment for Influenza Surveillance Networks
PLOS Computational Biology: published April 12, 2012 | https://doi.org/10.1371/journal.pcbi.1002472
Geometric Theory Predicts Bifurcations in Minimal Wiring Cost Trees in Biology Are Flat
PLOS Computational Biology: published April 12, 2012 | https://doi.org/10.1371/journal.pcbi.1002474
Impact of Adaptation Currents on Synchronization of Coupled Exponential Integrate-and-Fire Neurons
PLOS Computational Biology: published April 12, 2012 | https://doi.org/10.1371/journal.pcbi.1002478
Establishment and Validation of Computational Model for MT1-MMP Dependent ECM Degradation and Intervention Strategies
PLOS Computational Biology: published April 12, 2012 | https://doi.org/10.1371/journal.pcbi.1002479
Mapping the Environmental Fitness Landscape of a Synthetic Gene Circuit
PLOS Computational Biology: published April 12, 2012 | https://doi.org/10.1371/journal.pcbi.1002480
Replication Fork Polarity Gradients Revealed by Megabase-Sized U-Shaped Replication Timing Domains in Human Cell Lines
PLOS Computational Biology: published April 5, 2012 | https://doi.org/10.1371/journal.pcbi.1002443
Molecular Machines in the Synapse: Overlapping Protein Sets Control Distinct Steps in Neurosecretion
PLOS Computational Biology: published April 5, 2012 | https://doi.org/10.1371/journal.pcbi.1002450
Evolutionary Game Theory and Social Learning Can Determine How Vaccine Scares Unfold
PLOS Computational Biology: published April 5, 2012 | https://doi.org/10.1371/journal.pcbi.1002452
Automatic Filtering and Substantiation of Drug Safety Signals
PLOS Computational Biology: published April 5, 2012 | https://doi.org/10.1371/journal.pcbi.1002457
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What Can Causal Networks Tell Us about Metabolic Pathways?
PLOS Computational Biology: published April 5, 2012 | https://doi.org/10.1371/journal.pcbi.1002458
Parameters in Dynamic Models of Complex Traits are Containers of Missing Heritability
PLOS Computational Biology: published April 5, 2012 | https://doi.org/10.1371/journal.pcbi.1002459
Genome-Scale Modeling of Light-Driven Reductant Partitioning and Carbon Fluxes in Diazotrophic Unicellular Cyanobacterium Cyanothece sp. ATCC 51142
PLOS Computational Biology: published April 5, 2012 | https://doi.org/10.1371/journal.pcbi.1002460
Energetic Selection of Topology in Ferredoxins
PLOS Computational Biology: published April 5, 2012 | https://doi.org/10.1371/journal.pcbi.1002463
RNA-Seq Mapping and Detection of Gene Fusions with a Suffix Array Algorithm
PLOS Computational Biology: published April 5, 2012 | https://doi.org/10.1371/journal.pcbi.1002464
On Conduction in a Bacterial Sodium Channel
PLOS Computational Biology: published April 5, 2012 | https://doi.org/10.1371/journal.pcbi.1002476