Table of Contents: February 2013


Electrostatic field lines generated by the atomic charges of human spermine synthase dimer.

Image Credit: Marharyta Petukh, Zhe Zhang, Emil Alexov, Clemson University
Issue Image

The electrostatic field forms three distinctive funnels leading to the vicinity of the active sites. These funnels serve as electrostatic guide for the positively charged spermidine substrate. Coloring scale data range: -1; 1 (blue, positive; red, negative). Calculated with DelPhi and visualized with VMD. See Zhang, et al.


Research Articles

Discriminating External and Internal Causes for Heading Changes in Freely Flying Drosophila

Andrea Censi, Andrew D. Straw, Rosalyn W. Sayaman, Richard M. Murray, Michael H. Dickinson

Collective States, Multistability and Transitional Behavior in Schooling Fish

Kolbjørn Tunstrøm, Yael Katz, Christos C. Ioannou, Cristián Huepe, Matthew J. Lutz, Iain D. Couzin

Spartan: A Comprehensive Tool for Understanding Uncertainty in Simulations of Biological Systems

Kieran Alden, Mark Read, Jon Timmis, Paul S. Andrews, Henrique Veiga-Fernandes, Mark Coles

The Vast, Conserved Mammalian lincRNome

David Managadze, Alexander E. Lobkovsky, Yuri I. Wolf, Svetlana A. Shabalina, Igor B. Rogozin, Eugene V. Koonin

Functional Connectivity in Islets of Langerhans from Mouse Pancreas Tissue Slices

Andraž Stožer, Marko Gosak, Jurij Dolenšek, Matjaž Perc, Marko Marhl, Marjan Slak Rupnik, Dean Korošak

Enhancing Human Spermine Synthase Activity by Engineered Mutations

Zhe Zhang, Yueli Zheng, Margo Petukh, Anthony Pegg, Yoshihiko Ikeguchi, Emil Alexov

No Evidence for an Item Limit in Change Detection

Shaiyan Keshvari, Ronald van den Berg, Wei Ji Ma

Analysis of a Gene Regulatory Cascade Mediating Circadian Rhythm in Zebrafish

Ying Li, Guang Li, Haifang Wang, Jiulin Du, Jun Yan

Significantly Improved HIV Inhibitor Efficacy Prediction Employing Proteochemometric Models Generated From Antivirogram Data

Gerard J. P. van Westen, Alwin Hendriks, Jörg K. Wegner, Adriaan P. IJzerman, Herman W. T. van Vlijmen, Andreas Bender

Mutational Analysis of the High-Affinity Zinc Binding Site Validates a Refined Human Dopamine Transporter Homology Model

Thomas Stockner, Therese R. Montgomery, Oliver Kudlacek, Rene Weissensteiner, Gerhard F. Ecker, Michael Freissmuth, Harald H. Sitte

Modelling Trial-by-Trial Changes in the Mismatch Negativity

Falk Lieder, Jean Daunizeau, Marta I. Garrido, Karl J. Friston, Klaas E. Stephan

Evidence for Model-based Computations in the Human Amygdala during Pavlovian Conditioning

Charlotte Prévost, Daniel McNamee, Ryan K. Jessup, Peter Bossaerts, John P. O'Doherty

Biomolecular Events in Cancer Revealed by Attractor Metagenes

Wei-Yi Cheng, Tai-Hsien Ou Yang, Dimitris Anastassiou

Multi-Population Classical HLA Type Imputation

Alexander Dilthey, Stephen Leslie, Loukas Moutsianas, Judong Shen, Charles Cox, Matthew R. Nelson, Gil McVean

Transcranial Electrical Stimulation Accelerates Human Sleep Homeostasis

Davide Reato, Fernando Gasca, Abhishek Datta, Marom Bikson, Lisa Marshall, Lucas C. Parra

Getting More Out of Biomedical Documents with GATE's Full Lifecycle Open Source Text Analytics

Hamish Cunningham, Valentin Tablan, Angus Roberts, Kalina Bontcheva

Linking Proteomic and Transcriptional Data through the Interactome and Epigenome Reveals a Map of Oncogene-induced Signaling

Shao-shan Carol Huang, David C. Clarke, Sara J. C. Gosline, Adam Labadorf, Candace R. Chouinard, William Gordon, Douglas A. Lauffenburger, Ernest Fraenkel

Delay Selection by Spike-Timing-Dependent Plasticity in Recurrent Networks of Spiking Neurons Receiving Oscillatory Inputs

Robert R. Kerr, Anthony N. Burkitt, Doreen A. Thomas, Matthieu Gilson, David B. Grayden

The Timing and Targeting of Treatment in Influenza Pandemics Influences the Emergence of Resistance in Structured Populations

Benjamin M. Althouse, Oscar Patterson-Lomba, Georg M. Goerg, Laurent Hébert-Dufresne