The newly developed Druggable Site Visualizer (DSV) tool enables easy inspection of druggable sites on configurational ensembles. See Robertson et al.
Image Credit: James C. Robertson and Riccardo Baron, Department of Medicinal Chemistry, The University of Utah, U.S.A
Editorial
Ten Simple Rules for Writing a Literature Review
PLOS Computational Biology: published July 18, 2013 | https://doi.org/10.1371/journal.pcbi.1003149
Review
Information and Efficiency in the Nervous System—A Synthesis
PLOS Computational Biology: published July 25, 2013 | https://doi.org/10.1371/journal.pcbi.1003157
Research Articles
Models of Self-Peptide Sampling by Developing T Cells Identify Candidate Mechanisms of Thymic Selection
PLOS Computational Biology: published July 25, 2013 | https://doi.org/10.1371/journal.pcbi.1003102
‘HypothesisFinder:’ A Strategy for the Detection of Speculative Statements in Scientific Text
PLOS Computational Biology: published July 25, 2013 | https://doi.org/10.1371/journal.pcbi.1003117
Co-expression Profiling of Autism Genes in the Mouse Brain
PLOS Computational Biology: published July 25, 2013 | https://doi.org/10.1371/journal.pcbi.1003128
Spatial Stochastic Dynamics Enable Robust Cell Polarization
PLOS Computational Biology: published July 25, 2013 | https://doi.org/10.1371/journal.pcbi.1003139
Efficient Partitioning of Memory Systems and Its Importance for Memory Consolidation
PLOS Computational Biology: published July 25, 2013 | https://doi.org/10.1371/journal.pcbi.1003146
Multi-study Integration of Brain Cancer Transcriptomes Reveals Organ-Level Molecular Signatures
PLOS Computational Biology: published July 25, 2013 | https://doi.org/10.1371/journal.pcbi.1003148
A Mixture of Delta-Rules Approximation to Bayesian Inference in Change-Point Problems
PLOS Computational Biology: published July 25, 2013 | https://doi.org/10.1371/journal.pcbi.1003150
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PLOS Computational Biology: published July 25, 2013 | https://doi.org/10.1371/journal.pcbi.1003156
Organism-Adapted Specificity of the Allosteric Regulation of Pyruvate Kinase in Lactic Acid Bacteria
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A Family of Algorithms for Computing Consensus about Node State from Network Data
PLOS Computational Biology: published July 18, 2013 | https://doi.org/10.1371/journal.pcbi.1003109
The Role of Multiple Marks in Epigenetic Silencing and the Emergence of a Stable Bivalent Chromatin State
PLOS Computational Biology: published July 18, 2013 | https://doi.org/10.1371/journal.pcbi.1003121
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PLOS Computational Biology: published July 18, 2013 | https://doi.org/10.1371/journal.pcbi.1003124
A Model for the Self-Organization of Vesicular Flux and Protein Distributions in the Golgi Apparatus
PLOS Computational Biology: published July 18, 2013 | https://doi.org/10.1371/journal.pcbi.1003125
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PLOS Computational Biology: published July 18, 2013 | https://doi.org/10.1371/journal.pcbi.1003126
Gain Control Network Conditions in Early Sensory Coding
PLOS Computational Biology: published July 18, 2013 | https://doi.org/10.1371/journal.pcbi.1003133
Charles Bonnet Syndrome: Evidence for a Generative Model in the Cortex?
PLOS Computational Biology: published July 18, 2013 | https://doi.org/10.1371/journal.pcbi.1003134
Frequency Dependence of Signal Power and Spatial Reach of the Local Field Potential
PLOS Computational Biology: published July 18, 2013 | https://doi.org/10.1371/journal.pcbi.1003137
Dynamic Fluctuations Provide the Basis of a Conformational Switch Mechanism in Apo Cyclic AMP Receptor Protein
PLOS Computational Biology: published July 18, 2013 | https://doi.org/10.1371/journal.pcbi.1003141
Epidemiologically Optimal Static Networks from Temporal Network Data
PLOS Computational Biology: published July 18, 2013 | https://doi.org/10.1371/journal.pcbi.1003142
Inferring Nonlinear Neuronal Computation Based on Physiologically Plausible Inputs
PLOS Computational Biology: published July 18, 2013 | https://doi.org/10.1371/journal.pcbi.1003143
Structural Disorder Provides Increased Adaptability for Vesicle Trafficking Pathways
PLOS Computational Biology: published July 18, 2013 | https://doi.org/10.1371/journal.pcbi.1003144
Statistical Analysis of Molecular Signal Recording
PLOS Computational Biology: published July 18, 2013 | https://doi.org/10.1371/journal.pcbi.1003145
Improving Pharmacokinetic-Pharmacodynamic Modeling to Investigate Anti-Infective Chemotherapy with Application to the Current Generation of Antimalarial Drugs
PLOS Computational Biology: published July 18, 2013 | https://doi.org/10.1371/journal.pcbi.1003151
GEMINI: Integrative Exploration of Genetic Variation and Genome Annotations
PLOS Computational Biology: published July 18, 2013 | https://doi.org/10.1371/journal.pcbi.1003153
A Systematic Framework for Molecular Dynamics Simulations of Protein Post-Translational Modifications
PLOS Computational Biology: published July 18, 2013 | https://doi.org/10.1371/journal.pcbi.1003154
Variations within Class-A β-Lactamase Physiochemical Properties Reflect Evolutionary and Environmental Patterns, but not Antibiotic Specificity
PLOS Computational Biology: published July 18, 2013 | https://doi.org/10.1371/journal.pcbi.1003155
Expanding the Druggable Space of the LSD1/CoREST Epigenetic Target: New Potential Binding Regions for Drug-Like Molecules, Peptides, Protein Partners, and Chromatin
PLOS Computational Biology: published July 18, 2013 | https://doi.org/10.1371/journal.pcbi.1003158
Consistent Estimation of Gibbs Energy Using Component Contributions
PLOS Computational Biology: published July 11, 2013 | https://doi.org/10.1371/journal.pcbi.1003098
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Towards Predicting the Response of a Solid Tumour to Chemotherapy and Radiotherapy Treatments: Clinical Insights from a Computational Model
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Hierarchical Modeling for Rare Event Detection and Cell Subset Alignment across Flow Cytometry Samples
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Transcription Factor Binding Profiles Reveal Cyclic Expression of Human Protein-coding Genes and Non-coding RNAs
PLOS Computational Biology: published July 11, 2013 | https://doi.org/10.1371/journal.pcbi.1003132
Genetic Selection for Context-Dependent Stochastic Phenotypes: Sp1 and TATA Mutations Increase Phenotypic Noise in HIV-1 Gene Expression
PLOS Computational Biology: published July 11, 2013 | https://doi.org/10.1371/journal.pcbi.1003135
New Universal Rules of Eukaryotic Translation Initiation Fidelity
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Distinct Allelic Patterns of Nanog Expression Impart Embryonic Stem Cell Population Heterogeneity
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Predicting Network Activity from High Throughput Metabolomics
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