The earliest events in host defense against Candida species fungal pathogens involve the recruitment of anti-fungal receptors to specialized cellular contact sites. Image bioinformatic approaches permit quantitative dissection of spatiotemporal receptor distributions along this complex interface. Human immature dendritic cells (foreground right) recruit DC-SIGN (green) and CD206 (red) to capture C. albicans yeast (yellow), achieving up to two orders of magnitude enrichment of these receptors at the contact site. See Graus et al.
Image Credit: Matthew S. Graus, Aaron K. Neumann
Editorial
Ten Simple Rules for Internship in a Pharmaceutical Company
PLOS Computational Biology: published May 8, 2014 | https://doi.org/10.1371/journal.pcbi.1003600
Messages from ISCB
Paving the Way Towards a Successful and Fulfilling Career in Computational Biology
PLOS Computational Biology: published May 1, 2014 | https://doi.org/10.1371/journal.pcbi.1003593
2014 ISCB Accomplishment by a Senior Scientist Award: Gene Myers
PLOS Computational Biology: published May 22, 2014 | https://doi.org/10.1371/journal.pcbi.1003621
Learn from the Best
PLOS Computational Biology: published May 29, 2014 | https://doi.org/10.1371/journal.pcbi.1003645
Review
Towards Structural Systems Pharmacology to Study Complex Diseases and Personalized Medicine
PLOS Computational Biology: published May 15, 2014 | https://doi.org/10.1371/journal.pcbi.1003554
Research Articles
Interplay of Intrinsic and Synaptic Conductances in the Generation of High-Frequency Oscillations in Interneuronal Networks with Irregular Spiking
PLOS Computational Biology: published May 1, 2014 | https://doi.org/10.1371/journal.pcbi.1003574
A Computational Model for the Analysis of Lipoprotein Distributions in the Mouse: Translating FPLC Profiles to Lipoprotein Metabolism
PLOS Computational Biology: published May 1, 2014 | https://doi.org/10.1371/journal.pcbi.1003579
Bistable Dynamics Underlying Excitability of Ion Homeostasis in Neuron Models
PLOS Computational Biology: published May 1, 2014 | https://doi.org/10.1371/journal.pcbi.1003551
Determining Effects of Non-synonymous SNPs on Protein-Protein Interactions using Supervised and Semi-supervised Learning
PLOS Computational Biology: published May 1, 2014 | https://doi.org/10.1371/journal.pcbi.1003592
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Slow Feature Analysis on Retinal Waves Leads to V1 Complex Cells
PLOS Computational Biology: published May 8, 2014 | https://doi.org/10.1371/journal.pcbi.1003564
From the Phenomenology to the Mechanisms of Consciousness: Integrated Information Theory 3.0
PLOS Computational Biology: published May 8, 2014 | https://doi.org/10.1371/journal.pcbi.1003588
NbIT - A New Information Theory-Based Analysis of Allosteric Mechanisms Reveals Residues that Underlie Function in the Leucine Transporter LeuT
PLOS Computational Biology: published May 1, 2014 | https://doi.org/10.1371/journal.pcbi.1003603
A Computational Framework for Analyzing Stochasticity in Gene Expression
PLOS Computational Biology: published May 8, 2014 | https://doi.org/10.1371/journal.pcbi.1003596
Effects of Specular Highlights on Perceived Surface Convexity
PLOS Computational Biology: published May 8, 2014 | https://doi.org/10.1371/journal.pcbi.1003576
Combined Role of Seizure-Induced Dendritic Morphology Alterations and Spine Loss in Newborn Granule Cells with Mossy Fiber Sprouting on the Hyperexcitability of a Computer Model of the Dentate Gyrus
PLOS Computational Biology: published May 8, 2014 | https://doi.org/10.1371/journal.pcbi.1003601
Linear Superposition and Prediction of Bacterial Promoter Activity Dynamics in Complex Conditions
PLOS Computational Biology: published May 8, 2014 | https://doi.org/10.1371/journal.pcbi.1003602
Modelling Negative Feedback Networks for Activating Transcription Factor 3 Predicts a Dominant Role for miRNAs in Immediate Early Gene Regulation
PLOS Computational Biology: published May 8, 2014 | https://doi.org/10.1371/journal.pcbi.1003597
Synonymous Constraint Elements Show a Tendency to Encode Intrinsically Disordered Protein Segments
PLOS Computational Biology: published May 8, 2014 | https://doi.org/10.1371/journal.pcbi.1003607
A Simulated Intermediate State for Folding and Aggregation Provides Insights into ΔN6 β2-Microglobulin Amyloidogenic Behavior
PLOS Computational Biology: published May 8, 2014 | https://doi.org/10.1371/journal.pcbi.1003606
Predicting the Responses of Repetitively Firing Neurons to Current Noise
PLOS Computational Biology: published May 8, 2014 | https://doi.org/10.1371/journal.pcbi.1003612
Axonal Noise as a Source of Synaptic Variability
PLOS Computational Biology: published May 8, 2014 | https://doi.org/10.1371/journal.pcbi.1003615
Myxococcus xanthus Gliding Motors Are Elastically Coupled to the Substrate as Predicted by the Focal Adhesion Model of Gliding Motility
PLOS Computational Biology: published May 8, 2014 | https://doi.org/10.1371/journal.pcbi.1003619
Barriers to Cooperation Aid Ideological Rigidity and Threaten Societal Collapse
PLOS Computational Biology: published May 8, 2014 | https://doi.org/10.1371/journal.pcbi.1003618
Reciprocal Regulation as a Source of Ultrasensitivity in Two-Component Systems with a Bifunctional Sensor Kinase
PLOS Computational Biology: published May 8, 2014 | https://doi.org/10.1371/journal.pcbi.1003614
Structurally-Constrained Relationships between Cognitive States in the Human Brain
PLOS Computational Biology: published May 15, 2014 | https://doi.org/10.1371/journal.pcbi.1003591
Inference of RNA Polymerase II Transcription Dynamics from Chromatin Immunoprecipitation Time Course Data
PLOS Computational Biology: published May 15, 2014 | https://doi.org/10.1371/journal.pcbi.1003598
Mathematical Modeling Reveals Kinetics of Lymphocyte Recirculation in the Whole Organism
PLOS Computational Biology: published May 15, 2014 | https://doi.org/10.1371/journal.pcbi.1003586
Slow Noise in the Period of a Biological Oscillator Underlies Gradual Trends and Abrupt Transitions in Phasic Relationships in Hybrid Neural Networks
PLOS Computational Biology: published May 15, 2014 | https://doi.org/10.1371/journal.pcbi.1003622
ATPase Subdomain IA Is a Mediator of Interdomain Allostery in Hsp70 Molecular Chaperones
PLOS Computational Biology: published May 15, 2014 | https://doi.org/10.1371/journal.pcbi.1003624
Genomic Characterization of Large Heterochromatic Gaps in the Human Genome Assembly
PLOS Computational Biology: published May 15, 2014 | https://doi.org/10.1371/journal.pcbi.1003628
In-Vivo Real-Time Control of Protein Expression from Endogenous and Synthetic Gene Networks
PLOS Computational Biology: published May 15, 2014 | https://doi.org/10.1371/journal.pcbi.1003625
The Changing Geometry of a Fitness Landscape Along an Adaptive Walk
PLOS Computational Biology: published May 22, 2014 | https://doi.org/10.1371/journal.pcbi.1003520
Essential Plasticity and Redundancy of Metabolism Unveiled by Synthetic Lethality Analysis
PLOS Computational Biology: published May 22, 2014 | https://doi.org/10.1371/journal.pcbi.1003637
In Silico Screening of the Key Cellular Remodeling Targets in Chronic Atrial Fibrillation
PLOS Computational Biology: published May 22, 2014 | https://doi.org/10.1371/journal.pcbi.1003620
Evolution of Pathogen Specialisation in a Host Metapopulation: Joint Effects of Host and Pathogen Dispersal
PLOS Computational Biology: published May 22, 2014 | https://doi.org/10.1371/journal.pcbi.1003633
Spatial Generalization in Operant Learning: Lessons from Professional Basketball
PLOS Computational Biology: published May 22, 2014 | https://doi.org/10.1371/journal.pcbi.1003623
An Innovative Influenza Vaccination Policy: Targeting Last Season's Patients
PLOS Computational Biology: published May 22, 2014 | https://doi.org/10.1371/journal.pcbi.1003643
Are Current Atomistic Force Fields Accurate Enough to Study Proteins in Crowded Environments?
PLOS Computational Biology: published May 22, 2014 | https://doi.org/10.1371/journal.pcbi.1003638
A Signature of Attractor Dynamics in the CA3 Region of the Hippocampus
PLOS Computational Biology: published May 22, 2014 | https://doi.org/10.1371/journal.pcbi.1003641
Quantifying and Predicting the Effect of Exogenous Interleukin-7 on CD4+T Cells in HIV-1 Infection
PLOS Computational Biology: published May 22, 2014 | https://doi.org/10.1371/journal.pcbi.1003630
High-Resolution Modeling of Transmembrane Helical Protein Structures from Distant Homologues
PLOS Computational Biology: published May 22, 2014 | https://doi.org/10.1371/journal.pcbi.1003636
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Arterial Stiffening Provides Sufficient Explanation for Primary Hypertension
PLOS Computational Biology: published May 22, 2014 | https://doi.org/10.1371/journal.pcbi.1003634
Optimism as a Prior Belief about the Probability of Future Reward
PLOS Computational Biology: published May 22, 2014 | https://doi.org/10.1371/journal.pcbi.1003605
The Natural History of Biocatalytic Mechanisms
PLOS Computational Biology: published May 29, 2014 | https://doi.org/10.1371/journal.pcbi.1003642
Finding Novel Molecular Connections between Developmental Processes and Disease
PLOS Computational Biology: published May 29, 2014 | https://doi.org/10.1371/journal.pcbi.1003578
Exploration of the Dynamic Properties of Protein Complexes Predicted from Spatially Constrained Protein-Protein Interaction Networks
PLOS Computational Biology: published May 29, 2014 | https://doi.org/10.1371/journal.pcbi.1003654
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Inferring Host Gene Subnetworks Involved in Viral Replication
PLOS Computational Biology: published May 29, 2014 | https://doi.org/10.1371/journal.pcbi.1003626
A New Tool to Quantify Receptor Recruitment to Cell Contact Sites during Host-Pathogen Interaction
PLOS Computational Biology: published May 29, 2014 | https://doi.org/10.1371/journal.pcbi.1003639
Corrections
Correction: Single Sample Expression-Anchored Mechanisms Predict Survival in Head and Neck Cancer
PLOS Computational Biology: published May 2, 2014 | https://doi.org/10.1371/journal.pcbi.1003609
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Correction: Long Non-Coding RNA and Alternative Splicing Modulations in Parkinson’s Leukocytes Identified by RNA Sequencing
PLOS Computational Biology: published May 16, 2014 | https://doi.org/10.1371/journal.pcbi.1003647
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Correction: Quantitative Analysis of Glycerol Accumulation, Glycolysis and Growth under Hyper Osmotic Stress
PLOS Computational Biology: published May 22, 2014 | https://doi.org/10.1371/journal.pcbi.1003663