A model for transcription of NNS RNA viruses, which include Ebola, measles and VSV, is presented by Tang et al. The yellow strand represents the RNA genome fully encapsidated with proteins. The orange, ball-shaped objects are polymerases that transcribe the genome. Transcription initiates at the end of the genome as shown by polymerases on the left. The other polymerases (shown on the right) are attached to the template but slide randomly until they collide with the transcribing polymerases. These collisions kick sliding polymerases loose (top center) allowing them to diffuse to the end of the genome and start transcription.
Image Credit: Dave Meikle
Editorial
Ten Simple Rules for Finishing Your PhD
PLOS Computational Biology: published December 4, 2014 | https://doi.org/10.1371/journal.pcbi.1003954
Education
“Bioinformatics: Introduction and Methods,” a Bilingual Massive Open Online Course (MOOC) as a New Example for Global Bioinformatics Education
PLOS Computational Biology: published December 11, 2014 | https://doi.org/10.1371/journal.pcbi.1003955
Research Articles
ECOD: An Evolutionary Classification of Protein Domains
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The HIV Mutation Browser: A Resource for Human Immunodeficiency Virus Mutagenesis and Polymorphism Data
PLOS Computational Biology: published December 4, 2014 | https://doi.org/10.1371/journal.pcbi.1003951
Dynamics from Seconds to Hours in Hodgkin-Huxley Model with Time-Dependent Ion Concentrations and Buffer Reservoirs
PLOS Computational Biology: published December 4, 2014 | https://doi.org/10.1371/journal.pcbi.1003941
Live Imaging-Based Model Selection Reveals Periodic Regulation of the Stochastic G1/S Phase Transition in Vertebrate Axial Development
PLOS Computational Biology: published December 4, 2014 | https://doi.org/10.1371/journal.pcbi.1003957
Membrane Partitioning of Anionic, Ligand-Coated Nanoparticles Is Accompanied by Ligand Snorkeling, Local Disordering, and Cholesterol Depletion
PLOS Computational Biology: published December 4, 2014 | https://doi.org/10.1371/journal.pcbi.1003917
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Bayesian Inference of Sampled Ancestor Trees for Epidemiology and Fossil Calibration
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Some Work and Some Play: Microscopic and Macroscopic Approaches to Labor and Leisure
PLOS Computational Biology: published December 4, 2014 | https://doi.org/10.1371/journal.pcbi.1003894
The Amino Acid Alphabet and the Architecture of the Protein Sequence-Structure Map. I. Binary Alphabets
PLOS Computational Biology: published December 4, 2014 | https://doi.org/10.1371/journal.pcbi.1003946
Yielding Elastic Tethers Stabilize Robust Cell Adhesion
PLOS Computational Biology: published December 4, 2014 | https://doi.org/10.1371/journal.pcbi.1003971
Contradictory Behavioral Biases Result from the Influence of Past Stimuli on Perception
PLOS Computational Biology: published December 4, 2014 | https://doi.org/10.1371/journal.pcbi.1003948
Evolution of the Division of Labor between Genes and Enzymes in the RNA World
PLOS Computational Biology: published December 4, 2014 | https://doi.org/10.1371/journal.pcbi.1003936
Intrinsic Neuronal Properties Switch the Mode of Information Transmission in Networks
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A Network Convergence Zone in the Hippocampus
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Lattice-Based Model of Ductal Carcinoma In Situ Suggests Rules for Breast Cancer Progression to an Invasive State
PLOS Computational Biology: published December 4, 2014 | https://doi.org/10.1371/journal.pcbi.1003997
Extensive Error in the Number of Genes Inferred from Draft Genome Assemblies
PLOS Computational Biology: published December 4, 2014 | https://doi.org/10.1371/journal.pcbi.1003998
Structure, Dynamics and Implied Gating Mechanism of a Human Cyclic Nucleotide-Gated Channel
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Detecting Functional Divergence after Gene Duplication through Evolutionary Changes in Posttranslational Regulatory Sequences
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Heterogeneity and Convergence of Olfactory First-Order Neurons Account for the High Speed and Sensitivity of Second-Order Neurons
PLOS Computational Biology: published December 4, 2014 | https://doi.org/10.1371/journal.pcbi.1003975
A Reaction-Diffusion Model of Cholinergic Retinal Waves
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Hippocampal Remapping Is Constrained by Sparseness rather than Capacity
PLOS Computational Biology: published December 4, 2014 | https://doi.org/10.1371/journal.pcbi.1003986
The Social Bayesian Brain: Does Mentalizing Make a Difference When We Learn?
PLOS Computational Biology: published December 4, 2014 | https://doi.org/10.1371/journal.pcbi.1003992
Developmental Self-Construction and -Configuration of Functional Neocortical Neuronal Networks
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A Systematic Computational Analysis of Biosynthetic Gene Cluster Evolution: Lessons for Engineering Biosynthesis
PLOS Computational Biology: published December 4, 2014 | https://doi.org/10.1371/journal.pcbi.1004016
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Uncoupled Analysis of Stochastic Reaction Networks in Fluctuating Environments
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PLOS Computational Biology: published December 11, 2014 | https://doi.org/10.1371/journal.pcbi.1003991
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Oscillation-Induced Signal Transmission and Gating in Neural Circuits
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Protein-Protein Docking with Dynamic Residue Protonation States
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Immuno-epidemiological Modeling of HIV-1 Predicts High Heritability of the Set-Point Virus Load, while Selection for CTL Escape Dominates Virulence Evolution
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Symmetry Restoring Bifurcation in Collective Decision-Making
PLOS Computational Biology: published December 18, 2014 | https://doi.org/10.1371/journal.pcbi.1003960
Two-Dimensionality of Yeast Colony Expansion Accompanied by Pattern Formation
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Deep Neural Networks Rival the Representation of Primate IT Cortex for Core Visual Object Recognition
PLOS Computational Biology: published December 18, 2014 | https://doi.org/10.1371/journal.pcbi.1003963
Segregating Complex Sound Sources through Temporal Coherence
PLOS Computational Biology: published December 18, 2014 | https://doi.org/10.1371/journal.pcbi.1003985
Bilinearity in Spatiotemporal Integration of Synaptic Inputs
PLOS Computational Biology: published December 18, 2014 | https://doi.org/10.1371/journal.pcbi.1004014
Metadynamics Simulations Reveal a Na+ Independent Exiting Path of Galactose for the Inward-Facing Conformation of vSGLT
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Multitask Learning of Signaling and Regulatory Networks with Application to Studying Human Response to Flu
PLOS Computational Biology: published December 18, 2014 | https://doi.org/10.1371/journal.pcbi.1003943
Glutamate Mediated Astrocytic Filtering of Neuronal Activity
PLOS Computational Biology: published December 18, 2014 | https://doi.org/10.1371/journal.pcbi.1003964
Evolution of Integrated Causal Structures in Animats Exposed to Environments of Increasing Complexity
PLOS Computational Biology: published December 18, 2014 | https://doi.org/10.1371/journal.pcbi.1003966
Corrections
Correction: Enhanced Regulatory Sequence Prediction Using Gapped k-mer Features
PLOS Computational Biology: published December 1, 2014 | https://doi.org/10.1371/journal.pcbi.1004035
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Correction: Cell Type Specific Alterations in Interchromosomal Networks across the Cell Cycle
PLOS Computational Biology: published December 9, 2014 | https://doi.org/10.1371/journal.pcbi.1004064
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Correction: Limits of Feedback Control in Bacterial Chemotaxis
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