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Table of Contents: February 2009

COVER

Zooming in on the voltage sensor.

Image Credit: Jyrki Hokkanen (The Finnish IT Center for Scientific Computing (CSC)).
Issue Image

The stability and gating motion of the voltage sensor domain (white) of the Kv1.2 ion channel in its natural environment within bilayers (orange) is a hot current research topic. Using extensive all-atom molecular dynamics simulations, a new study by Bjelkmar et al. sheds new light on these phenomena. Upon application of an electrical field, the voltage sensor S4 helix undergoes a secondary structure transition, orienting the positively charged arginine residues (yellow) in a way that seems to "prepare" them for the gating motion (see Bjelkmar et al., doi:10.1371/journal.pcbi.1000289).

Research Articles

Agent-Based Model of Therapeutic Adipose-Derived Stromal Cell Trafficking during Ischemia Predicts Ability To Roll on P-Selectin

Alexander M. Bailey, Michael B. Lawrence, Hulan Shang, Adam J. Katz, Shayn M. Peirce

Rapid Sampling of Molecular Motions with Prior Information Constraints

Barak Raveh, Angela Enosh, Ora Schueler-Furman, Dan Halperin

Identification of Potential Pathway Mediation Targets in Toll-like Receptor Signaling

Fan Li, Ines Thiele, Neema Jamshidi, Bernhard Ø. Palsson

Can Monkeys Choose Optimally When Faced with Noisy Stimuli and Unequal Rewards?

Samuel Feng, Philip Holmes, Alan Rorie, William T. Newsome

A Genome-Scale Metabolic Reconstruction of Mycoplasma genitalium, iPS189

Patrick F. Suthers, Madhukar S. Dasika, Vinay Satish Kumar, Gennady Denisov, John I. Glass, Costas D. Maranas

Statistical Dynamics of Flowing Red Blood Cells by Morphological Image Processing

John M. Higgins, David T. Eddington, Sangeeta N. Bhatia, L. Mahadevan