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Table of Contents: April 2009

COVER

Structural transitions of the chaperonin GroEL during its allosteric cycle.

Image Credit: The image was created by Zheng Yang (University of Pittsburgh, United States of America).
Issue Image

The bacterial chaperonin GroEL is an ATP-regulated molecular machine. It assists misfolded or partially folded proteins to unfold and refold into the correct native structure. The molecule consists of two rings, each composed of seven subunits. A dominant mechanism of motion during this process, which is predicted by the elastic network model, is the concerted counter-rotation of the two rings. This image displays four successive snapshots, viewed from the top, corresponding to successive steps of this allosteric process (see Yang et al., doi:10.1371/journal.pcbi.1000360).

Editorial

Ten Simple Rules To Combine Teaching and Research

Quentin Vicens, Philip E. Bourne

Message from ISCB

Review

Adventures in Semantic Publishing: Exemplar Semantic Enhancements of a Research Article

David Shotton, Katie Portwin, Graham Klyne, Alistair Miles

Research Articles

A Structural Model of the Pore-Forming Region of the Skeletal Muscle Ryanodine Receptor (RyR1)

Srinivas Ramachandran, Adrian W. R. Serohijos, Le Xu, Gerhard Meissner, Nikolay V. Dokholyan

Mapping Gene Associations in Human Mitochondria using Clinical Disease Phenotypes

Curt Scharfe, Henry Horng-Shing Lu, Jutta K. Neuenburg, Edward A. Allen, Guan-Cheng Li, Thomas Klopstock, Tina M. Cowan, Gregory M. Enns, Ronald W. Davis

Design Principles for Riboswitch Function

Chase L. Beisel, Christina D. Smolke

Dissociating Variability and Effort as Determinants of Coordination

Ian O'Sullivan, Etienne Burdet, Jörn Diedrichsen

The Role of Environmental Transmission in Recurrent Avian Influenza Epidemics

Romulus Breban, John M. Drake, David E. Stallknecht, Pejman Rohani

Information Flow Analysis of Interactome Networks

Patrycja Vasilyev Missiuro, Kesheng Liu, Lihua Zou, Brian C. Ross, Guoyan Zhao, Jun S. Liu, Hui Ge

A Dynamic Network Approach for the Study of Human Phenotypes

César A. Hidalgo, Nicholas Blumm, Albert-László Barabási, Nicholas A. Christakis

Predicting Phenotypic Diversity and the Underlying Quantitative Molecular Transitions

Claudiu A. Giurumescu, Paul W. Sternberg, Anand R. Asthagiri

An Analytically Solvable Model for Rapid Evolution of Modular Structure

Nadav Kashtan, Avi E. Mayo, Tomer Kalisky, Uri Alon

Estimating the Location and Spatial Extent of a Covert Anthrax Release

Judith Legrand, Joseph R. Egan, Ian M. Hall, Simon Cauchemez, Steve Leach, Neil M. Ferguson

Systems Analysis of Bioenergetics and Growth of the Extreme Halophile Halobacterium salinarum

Orland Gonzalez, Susanne Gronau, Friedhelm Pfeiffer, Eduardo Mendoza, Ralf Zimmer, Dieter Oesterhelt

Evolutionary Epidemiology of Drug-Resistance in Space

Florence Débarre, Thomas Lenormand, Sylvain Gandon

The Homeostasis of Plasmodium falciparum-Infected Red Blood Cells

Jakob M. A. Mauritz, Alessandro Esposito, Hagai Ginsburg, Clemens F. Kaminski, Teresa Tiffert, Virgilio L. Lew

Fuzzy Logic Analysis of Kinase Pathway Crosstalk in TNF/EGF/Insulin-Induced Signaling

Bree B. Aldridge, Julio Saez-Rodriguez, Jeremy L. Muhlich, Peter K. Sorger, Douglas A. Lauffenburger

Maximal Extraction of Biological Information from Genetic Interaction Data

Gregory W. Carter, David J. Galas, Timothy Galitski