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Table of Contents: July 2006

COVER

Rearrangement of protein structure

Image Credit: Protein structures visualized with PyMOL software. Design by Nikolay V.
Issue Image

Subtle structural changes lead to distinct packing of the protein core. These changes appear due to accumulating mutations in the closely related homologous protein families. These random mutations in the ancestor protein (top) can lead to the rearrangement of the protein structure (bottom), which results in the formation of a distinct fold family (see Ding and Dokholyan).

Review

Research Articles

Module-Based Analysis of Robustness Tradeoffs in the Heat Shock Response System

Hiroyuki Kurata, Hana El-Samad, Rei Iwasaki, Hisao Ohtake, John C Doyle, Irina Grigorova, Carol A Gross, Mustafa Khammash

Circadian Rhythmicity by Autocatalysis

Arun Mehra, Christian I Hong, Mi Shi, Jennifer J Loros, Jay C Dunlap, Peter Ruoff

Extracting Gene Networks for Low-Dose Radiation Using Graph Theoretical Algorithms

Brynn H Voy, Jon A Scharff, Andy D Perkins, Arnold M Saxton, Bhavesh Borate, Elissa J Chesler, Lisa K Branstetter, Michael A Langston

Toward a Census of Bacteria in Soil

Patrick D Schloss, Jo Handelsman

Intronic Alternative Splicing Regulators Identified by Comparative Genomics in Nematodes

Jennifer L Kabat, Sergio Barberan-Soler, Paul McKenna, Hiram Clawson, Tracy Farrer, Alan M Zahler

Evolutionary and Physiological Importance of Hub Proteins

Nizar N Batada, Laurence D Hurst, Mike Tyers

Correspondence

Authors' Reply

Hung D Nguyen, Maki Yoshihama, Naoya Kenmochi

Correction

Correction: How Does Cross-Reactive Stimulation Affect the Longevity of CD8+ T Cell Memory?

Vitaly V Ganusov, Sergei S Pilyugin, Rafi Ahmed, Rustom Antia